Fields »
ABOUT
HELP
BLOG
PGD

GENERAL INFORMATION

Gene name

 PGD

Gene description

 Phosphogluconate dehydrogenase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA031314
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031314

GENE INFORMATION

Gene name

 PGD

Synonyms

Description

 Phosphogluconate dehydrogenase (HGNC Symbol)

Entrez gene summary

 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

Chromosome

 1

Cytoband

 p36.22

Chromosome location (bp)

 10398592 - 10420144

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142657 (version 83.38)

Entrez gene

 5226

UniProt

 P52209 (UniProt - Evidence at protein level)

neXtProt

 NX_P52209

Antibodypedia

 PGD antibodies

PROTEIN BROWSER
PGD-001
PGD-002
PGD-006
PGD-007
PGD-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PGD-001
ENSP00000270776
ENST00000270776
P52209 [Direct mapping]
6-phosphogluconate dehydrogenase, decarboxylating
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004616 [phosphogluconate dehydrogenase (decarboxylating) activity]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006098 [pentose-phosphate shunt]
GO:0009051 [pentose-phosphate shunt, oxidative branch]
GO:0019322 [pentose biosynthetic process]
GO:0019521 [D-gluconate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 483 aa
53.1 kDa 		No 0
PGD-002
ENSP00000466358
ENST00000491493
K7EM49 [Direct mapping]
6-phosphogluconate dehydrogenase, decarboxylating
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004616 [phosphogluconate dehydrogenase (decarboxylating) activity]
GO:0006098 [pentose-phosphate shunt]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
Show all
 205 aa
22.3 kDa 		No 0
PGD-006
ENSP00000466574
ENST00000465632
K7EMN2 [Direct mapping]
6-phosphogluconate dehydrogenase, decarboxylating
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004616 [phosphogluconate dehydrogenase (decarboxylating) activity]
GO:0055114 [oxidation-reduction process]
Show all
 160 aa
17.3 kDa 		No 0
PGD-007
ENSP00000466156
ENST00000483936
K7ELN9 [Direct mapping]
6-phosphogluconate dehydrogenase, decarboxylating
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004616 [phosphogluconate dehydrogenase (decarboxylating) activity]
GO:0006098 [pentose-phosphate shunt]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
Show all
 224 aa
24.8 kDa 		No 0
PGD-008
ENSP00000467362
ENST00000460189
K7EPF6 [Direct mapping]
6-phosphogluconate dehydrogenase, decarboxylating
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004616 [phosphogluconate dehydrogenase (decarboxylating) activity]
GO:0006098 [pentose-phosphate shunt]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
Show all
 256 aa
27.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.