Expression of MYOM3 in cancer - Summary - The Human Protein Atlas

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MYOM3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MYOM3
Gene description	Myomesin 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (renal cancer)
HPA (cell line):	Cell line enhanced (A549, Hep G2)
HPA (normal tissue):	Group enriched (heart muscle, kidney, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

RNA- data suggests expression in skeletal and heart muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 2 antibodies. HPA028132 , HPA029752
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028132	HPA029752

GENE INFORMATION
Gene name	MYOM3 (HGNC Symbol)
Synonyms	FLJ35961
Description	Myomesin 3 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p36.11
Chromosome location (bp)	24056035 - 24112175
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142661 (version 83.38)
Entrez gene	127294
UniProt	Q5VTT5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5VTT5
Antibodypedia	MYOM3 antibodies

PROTEIN BROWSER

MYOM3-001	MYOM3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYOM3-001 ENSP00000363557 ENST00000374434	Q5VTT5 [Direct mapping] Myomesin-3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0031430 [M band] GO:0042803 [protein homodimerization activity] Show all	1437 aa 162.2 kDa	No	0
MYOM3-003 ENSP00000342689 ENST00000338909	Q5VTT5 [Direct mapping] Myomesin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0031430 [M band] GO:0042803 [protein homodimerization activity] Show all	330 aa 37.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.