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FCN3

GENERAL INFORMATION

Gene name

 FCN3

Gene description

 Ficolin (collagen/fibrinogen domain containing) 3

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (liver, lung)
GTEx:Tissue enriched (lung)
FANTOM5:Tissue enhanced (liver, lung)

Protein evidence

 Evidence at protein level

Protein expression

 Extracellular deposits and cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
CAB025945
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, lung)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver, lung)

GENE INFORMATION

Gene name

 FCN3 (HGNC Symbol)

Synonyms

 FCNH, HAKA1

Description

 Ficolin (collagen/fibrinogen domain containing) 3 (HGNC Symbol)

Entrez gene summary

 Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 27369112 - 27374824

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142748 (version 83.38)

Entrez gene

 8547

UniProt

 O75636 (UniProt - Evidence at protein level)

neXtProt

 NX_O75636

Antibodypedia

 FCN3 antibodies

PROTEIN BROWSER
FCN3-001
FCN3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FCN3-001
ENSP00000270879
ENST00000270879
O75636 [Direct mapping]
Ficolin-3
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001867 [complement activation, lectin pathway]
GO:0003823 [antigen binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0006956 [complement activation]
GO:0030246 [carbohydrate binding]
GO:0043654 [recognition of apoptotic cell]
GO:0045087 [innate immune response]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0051607 [defense response to virus]
GO:0072562 [blood microparticle]
GO:1902679 [negative regulation of RNA biosynthetic process]
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 299 aa
32.9 kDa 		Yes 0
FCN3-002
ENSP00000347077
ENST00000354982
O75636 [Direct mapping]
Ficolin-3
Q6UXM4 [Target identity:100%; Query identity:100%]
Ficolin (Collagen/fibrinogen domain containing) 3 (Hakata antigen), isoform CRA_b; NL3
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001867 [complement activation, lectin pathway]
GO:0003823 [antigen binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0006956 [complement activation]
GO:0030246 [carbohydrate binding]
GO:0043654 [recognition of apoptotic cell]
GO:0045087 [innate immune response]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0051607 [defense response to virus]
GO:0072562 [blood microparticle]
GO:1902679 [negative regulation of RNA biosynthetic process]
Show all
 288 aa
31.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.