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SERBP1

GENERAL INFORMATION

Gene name

 SERBP1

Gene description

 SERPINE1 mRNA binding protein 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA020559 , CAB026297
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA020559
CAB026297

GENE INFORMATION

Gene name

 SERBP1 (HGNC Symbol)

Synonyms

 CGI-55, CHD3IP, DKFZP564M2423, HABP4L, PAI-RBP1, PAIRBP1

Description

 SERPINE1 mRNA binding protein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p31.3

Chromosome location (bp)

 67407810 - 67430415

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142864 (version 83.38)

Entrez gene

 26135

UniProt

 Q8NC51 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NC51

Antibodypedia

 SERBP1 antibodies

PROTEIN BROWSER
SERBP1-001
SERBP1-002
SERBP1-005
SERBP1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SERBP1-001
ENSP00000360033
ENST00000370994
Q8NC51 [Direct mapping]
Plasminogen activator inhibitor 1 RNA-binding protein
Q5VU21 [Target identity:100%; Query identity:100%]
PAI-1 mRNA-binding protein variant; cDNA, FLJ92551, Homo sapiens PAI-1 mRNA-binding protein (PAI-RBP1), mRNA
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0016020 [membrane]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
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 387 aa
42.4 kDa 		No 0
SERBP1-002
ENSP00000360034
ENST00000370995
Q8NC51 [Direct mapping]
Plasminogen activator inhibitor 1 RNA-binding protein
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0042981 [regulation of apoptotic process]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
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 408 aa
45 kDa 		No 0
SERBP1-005
ENSP00000354591
ENST00000361219
Q8NC51 [Direct mapping]
Plasminogen activator inhibitor 1 RNA-binding protein
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0016020 [membrane]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
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 393 aa
43.1 kDa 		No 0
SERBP1-006
ENSP00000360029
ENST00000370990
Q8NC51 [Direct mapping]
Plasminogen activator inhibitor 1 RNA-binding protein
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0016020 [membrane]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
Show all
 402 aa
44.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.