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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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BCL10
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

BCL10

Gene description

B-cell CLL/lymphoma 10

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA017925 , CAB001944
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PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable) and colorectal cancer (favourable).
Liver cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA017925
CAB001944

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignancies displayed weak to moderate cytoplasmic positivity. Few cases of ovarian and liver cancers were strongly stained.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant tissues displayed weak to moderate cytoplasmic immunoreactivity. Strong staining was observed in malignant lymphomas and a few stomach- and lung cancers.

GENE INFORMATION

Gene name

BCL10 (HGNC Symbol)

Synonyms

c-E10, CARMEN, CIPER, CLAP, mE10

Description

B-cell CLL/lymphoma 10 (HGNC Symbol)

Entrez gene summary

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p22.3

Chromosome location (bp)

85266248 - 85277090

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142867 (version 83.38)

Entrez gene

8915

UniProt

O95999 (UniProt - Evidence at protein level)

neXtProt

NX_O95999

Antibodypedia

BCL10 antibodies

PROTEIN BROWSER

BCL10-001
BCL10-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL10-001
ENSP00000359612
ENST00000370580
O95999 [Direct mapping]
B-cell lymphoma/leukemia 10
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001772 [immunological synapse]
GO:0001783 [B cell apoptotic process]
GO:0001843 [neural tube closure]
GO:0002020 [protease binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002237 [response to molecule of bacterial origin]
GO:0002250 [adaptive immune response]
GO:0002906 [negative regulation of mature B cell apoptotic process]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0006968 [cellular defense response]
GO:0008022 [protein C-terminus binding]
GO:0008134 [transcription factor binding]
GO:0008219 [cell death]
GO:0009620 [response to fungus]
GO:0016064 [immunoglobulin mediated immune response]
GO:0019209 [kinase activator activity]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032094 [response to food]
GO:0032449 [CBM complex]
GO:0032765 [positive regulation of mast cell cytokine production]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042101 [T cell receptor complex]
GO:0042109 [lymphotoxin A biosynthetic process]
GO:0042226 [interleukin-6 biosynthetic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043130 [ubiquitin binding]
GO:0043234 [protein complex]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043422 [protein kinase B binding]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045416 [positive regulation of interleukin-8 biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050852 [T cell receptor signaling pathway]
GO:0050856 [regulation of T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0051059 [NF-kappaB binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0070231 [T cell apoptotic process]
GO:0071260 [cellular response to mechanical stimulus]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
233 aa
26.3 kDa
No 0
BCL10-201
ENSP00000480561
ENST00000620248
A0A087WWW9 [Direct mapping]
B-cell lymphoma/leukemia 10
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0042981 [regulation of apoptotic process]
Show all
156 aa
18.1 kDa
No 0

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