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Most malignant tissues displayed weak to moderate cytoplasmic immunoreactivity. Strong staining was observed in malignant lymphomas and a few stomach- and lung cancers.
GENE INFORMATION
Gene name
BCL10 (HGNC Symbol)
Synonyms
c-E10, CARMEN, CIPER, CLAP, mE10
Description
B-cell CLL/lymphoma 10 (HGNC Symbol)
Entrez gene summary
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001772 [immunological synapse] GO:0001783 [B cell apoptotic process] GO:0001843 [neural tube closure] GO:0002020 [protease binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002224 [toll-like receptor signaling pathway] GO:0002237 [response to molecule of bacterial origin] GO:0002250 [adaptive immune response] GO:0002906 [negative regulation of mature B cell apoptotic process] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005881 [cytoplasmic microtubule] GO:0005886 [plasma membrane] GO:0006968 [cellular defense response] GO:0008022 [protein C-terminus binding] GO:0008134 [transcription factor binding] GO:0008219 [cell death] GO:0009620 [response to fungus] GO:0016064 [immunoglobulin mediated immune response] GO:0019209 [kinase activator activity] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0031398 [positive regulation of protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0032094 [response to food] GO:0032449 [CBM complex] GO:0032765 [positive regulation of mast cell cytokine production] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042101 [T cell receptor complex] GO:0042109 [lymphotoxin A biosynthetic process] GO:0042226 [interleukin-6 biosynthetic process] GO:0042327 [positive regulation of phosphorylation] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130 [ubiquitin binding] GO:0043234 [protein complex] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043422 [protein kinase B binding] GO:0043621 [protein self-association] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045416 [positive regulation of interleukin-8 biosynthetic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046696 [lipopolysaccharide receptor complex] GO:0048471 [perinuclear region of cytoplasm] GO:0050852 [T cell receptor signaling pathway] GO:0050856 [regulation of T cell receptor signaling pathway] GO:0050870 [positive regulation of T cell activation] GO:0051059 [NF-kappaB binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051259 [protein oligomerization] GO:0051260 [protein homooligomerization] GO:0051291 [protein heterooligomerization] GO:0070231 [T cell apoptotic process] GO:0071260 [cellular response to mechanical stimulus] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)