Cell atlas - MOB3C - The Human Protein Atlas

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MOB3C

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Intermediate filaments

Human cell
	Cytosol
	Intermediate Filaments

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GENERAL INFORMATION
Gene name	MOB3C
Gene description	MOB kinase activator 3C
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & intermediate filaments. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Intermediate filaments (uncertain), Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA057744
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & intermediate filaments. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Intermediate filaments (uncertain), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA057744	U-2 OS	Intermediate filaments
	HPA057744	U-2 OS	Cytosol
	HPA057744	U-251 MG	Intermediate filaments
	HPA057744	U-251 MG	Cytosol

GENE INFORMATION
Gene name	MOB3C (HGNC Symbol)
Synonyms	MOB1E, MOBKL2C
Description	MOB kinase activator 3C (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p33
Chromosome location (bp)	46607715 - 46616891
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142961 (version 83.38)
Entrez gene	148932
UniProt	Q70IA8 (UniProt - Evidence at protein level)
neXtProt	NX_Q70IA8
Antibodypedia	MOB3C antibodies

PROTEIN BROWSER

MOB3C-001	MOB3C-002	MOB3C-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MOB3C-001 ENSP00000271139 ENST00000271139	X6R3L3 [Direct mapping] MOB kinase activator 3C Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		268 aa 31.7 kDa	No	0
MOB3C-002 ENSP00000361008 ENST00000371940	Q70IA8 [Direct mapping] MOB kinase activator 3C Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0046872 [metal ion binding] Show all	216 aa 25.6 kDa	No	0
MOB3C-201 ENSP00000315113 ENST00000319928	Q70IA8 [Direct mapping] MOB kinase activator 3C Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0046872 [metal ion binding] Show all	216 aa 25.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.