Expression of CYP4B1 in cancer - Summary

GENERAL INFORMATION
Gene name	CYP4B1
Gene description	Cytochrome P450, family 4, subfamily B, polypeptide 1
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (urothelial cancer)
HPA (cell line):	Cell line enriched (RT4)
HPA (normal tissue):	Tissue enriched (lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including ciliated cells in fallopian tube and respiratory tact.

ANTIBODY IHC RELIABILITY
Data reliability description	Protein expression in respiratory epithelia can be correlated with lung RNA expression data.
Reliability score	Approved based on 1 antibody. HPA004331
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (urothelial cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA004331

GENE INFORMATION
Gene name	CYP4B1
Synonyms
Description	Cytochrome P450, family 4, subfamily B, polypeptide 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Two transcript variants encoding slightly different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p33
Chromosome location (bp)	46757838 - 46819413
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142973 (version 83.38)
Entrez gene	1580
UniProt	P13584 (UniProt - Evidence at protein level)
neXtProt	NX_P13584
Antibodypedia	CYP4B1 antibodies

PROTEIN BROWSER

CYP4B1-001	CYP4B1-002	CYP4B1-003	CYP4B1-010	CYP4B1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP4B1-001 ENSP00000271153 ENST00000271153	P13584 [Direct mapping] Cytochrome P450 4B1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0019825 [oxygen binding] GO:0020037 [heme binding] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070330 [aromatase activity] Show all	511 aa 59 kDa	No	1
CYP4B1-002 ENSP00000360991 ENST00000371923	P13584 [Direct mapping] Cytochrome P450 4B1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006725 [cellular aromatic compound metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008144 [drug binding] GO:0015643 [toxic substance binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0018585 [fluorene oxygenase activity] GO:0018879 [biphenyl metabolic process] GO:0018917 [fluorene metabolic process] GO:0019825 [oxygen binding] GO:0020037 [heme binding] GO:0042738 [exogenous drug catabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070330 [aromatase activity] Show all	512 aa 59.1 kDa	No	1
CYP4B1-003 ENSP00000360987 ENST00000371919	Q8IZB0 [Direct mapping] Cytochrome P450 4B1; Pulmonary cytochrome P450 4B1 variant Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	497 aa 57.2 kDa	No	1
CYP4B1-010 ENSP00000438995 ENST00000526297	F5H1Q8 [Direct mapping] Cytochrome P450 4B1 Show all	Predicted intracellular proteins Show all	GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	70 aa 8.1 kDa	No	0
CYP4B1-201 ENSP00000484629 ENST00000614163	Q8WWV1 [Direct mapping] Cytochrome P450 4B1; Cytochrome P450, family 4, subfamily B, polypeptide 1, isoform CRA_b; Truncated cytochrome P450 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005506 [iron ion binding] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	295 aa 34.2 kDa	No	1