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ALDH9A1

GENERAL INFORMATION

Gene name

 ALDH9A1

Gene description

 Aldehyde dehydrogenase 9 family, member A1

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA010873
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ALDH9A1 (HGNC Symbol)

Synonyms

 ALDH4, ALDH7, ALDH9, E3

Description

 Aldehyde dehydrogenase 9 family, member A1 (HGNC Symbol)

Entrez gene summary

 This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q24.1

Chromosome location (bp)

 165662216 - 165698863

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143149 (version 83.38)

Entrez gene

 223

UniProt

 P49189 (UniProt - Evidence at protein level)

neXtProt

 NX_P49189

Antibodypedia

 ALDH9A1 antibodies

PROTEIN BROWSER
ALDH9A1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALDH9A1-001
ENSP00000346827
ENST00000354775
P49189 [Direct mapping]
4-trimethylaminobutyraldehyde dehydrogenase 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed
B9EKV4 [Target identity:100%; Query identity:100%]
Aldehyde dehydrogenase 9 family, member A1
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0001889 [liver development]
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006081 [cellular aldehyde metabolic process]
GO:0008152 [metabolic process]
GO:0009083 [branched-chain amino acid catabolic process]
GO:0009437 [carnitine metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0019145 [aminobutyraldehyde dehydrogenase activity]
GO:0033737 [1-pyrroline dehydrogenase activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042445 [hormone metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043176 [amine binding]
GO:0044281 [small molecule metabolic process]
GO:0045329 [carnitine biosynthetic process]
GO:0047105 [4-trimethylammoniobutyraldehyde dehydrogenase activity]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 518 aa
56.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.