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ATP1B1

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GENERAL INFORMATION

Gene name

 ATP1B1

Gene description

 ATPase, Na+/K+ transporting, beta 1 polypeptide

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (SH-SY5Y, RPTEC TERT1)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, RPTEC TERT1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ATP1B1 (HGNC Symbol)

Synonyms

 ATP1B

Description

 ATPase, Na+/K+ transporting, beta 1 polypeptide (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]

Chromosome

 1

Cytoband

 q24.2

Chromosome location (bp)

 169105697 - 169132722

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143153 (version 83.38)

Entrez gene

 481

UniProt

 P05026 (UniProt - Evidence at protein level)

neXtProt

 NX_P05026

Antibodypedia

 ATP1B1 antibodies

PROTEIN BROWSER
ATP1B1-001
ATP1B1-002
ATP1B1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP1B1-001
ENSP00000356789
ENST00000367815
P05026 [Direct mapping]
Sodium/potassium-transporting ATPase subunit beta-1
A3KLL5 [Target identity:100%; Query identity:100%]
ATPase, Na+/K+ transporting, beta 1 polypeptide, isoform CRA_a; Na,K-ATPase beta 1 subunit; cDNA FLJ76773, highly similar to Homo sapiens ATPase, Na+/K+ transporting, beta 1 polypeptide (ATP1B1), transcript variant 1, mRNA
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001671 [ATPase activator activity]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0005391 [sodium:potassium-exchanging ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008144 [drug binding]
GO:0010107 [potassium ion import]
GO:0010468 [regulation of gene expression]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0014704 [intercalated disc]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0023026 [MHC class II protein complex binding]
GO:0030007 [cellular potassium ion homeostasis]
GO:0030955 [potassium ion binding]
GO:0031402 [sodium ion binding]
GO:0032781 [positive regulation of ATPase activity]
GO:0034220 [ion transmembrane transport]
GO:0036376 [sodium ion export from cell]
GO:0042383 [sarcolemma]
GO:0044861 [protein transport into plasma membrane raft]
GO:0046034 [ATP metabolic process]
GO:0050821 [protein stabilization]
GO:0050900 [leukocyte migration]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0055119 [relaxation of cardiac muscle]
GO:0060048 [cardiac muscle contraction]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
GO:0086009 [membrane repolarization]
GO:0086013 [membrane repolarization during cardiac muscle cell action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1901018 [positive regulation of potassium ion transmembrane transporter activity]
GO:1903278 [positive regulation of sodium ion export from cell]
GO:1903281 [positive regulation of calcium:sodium antiporter activity]
GO:1903288 [positive regulation of potassium ion import]
GO:1903561 [extracellular vesicle]
GO:1990573 [potassium ion import across plasma membrane]
Show all
 303 aa
35.1 kDa 		No 1
ATP1B1-002
ENSP00000356790
ENST00000367816
P05026 [Direct mapping]
Sodium/potassium-transporting ATPase subunit beta-1
A3KLL5 [Target identity:100%; Query identity:100%]
ATPase, Na+/K+ transporting, beta 1 polypeptide, isoform CRA_a; Na,K-ATPase beta 1 subunit; cDNA FLJ76773, highly similar to Homo sapiens ATPase, Na+/K+ transporting, beta 1 polypeptide (ATP1B1), transcript variant 1, mRNA
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001671 [ATPase activator activity]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0005391 [sodium:potassium-exchanging ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0005901 [caveola]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008144 [drug binding]
GO:0010107 [potassium ion import]
GO:0010468 [regulation of gene expression]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0014704 [intercalated disc]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016887 [ATPase activity]
GO:0023026 [MHC class II protein complex binding]
GO:0030001 [metal ion transport]
GO:0030007 [cellular potassium ion homeostasis]
GO:0030955 [potassium ion binding]
GO:0031402 [sodium ion binding]
GO:0032781 [positive regulation of ATPase activity]
GO:0034220 [ion transmembrane transport]
GO:0036376 [sodium ion export from cell]
GO:0042383 [sarcolemma]
GO:0043209 [myelin sheath]
GO:0044861 [protein transport into plasma membrane raft]
GO:0046034 [ATP metabolic process]
GO:0050821 [protein stabilization]
GO:0050900 [leukocyte migration]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0055119 [relaxation of cardiac muscle]
GO:0060048 [cardiac muscle contraction]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
GO:0086009 [membrane repolarization]
GO:0086013 [membrane repolarization during cardiac muscle cell action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1901018 [positive regulation of potassium ion transmembrane transporter activity]
GO:1903169 [regulation of calcium ion transmembrane transport]
GO:1903278 [positive regulation of sodium ion export from cell]
GO:1903281 [positive regulation of calcium:sodium antiporter activity]
GO:1903288 [positive regulation of potassium ion import]
GO:1903561 [extracellular vesicle]
GO:1990573 [potassium ion import across plasma membrane]
Show all
 303 aa
35.1 kDa 		No 1
ATP1B1-003
ENSP00000477015
ENST00000494797
V9GYR2 [Direct mapping]
Sodium/potassium-transporting ATPase subunit beta-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
Show all
 130 aa
15.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.