Expression of MPC2 in cancer - Summary - The Human Protein Atlas

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MPC2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MPC2
Gene description	Mitochondrial pyruvate carrier 2
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA056091
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA056091

GENE INFORMATION
Gene name	MPC2 (HGNC Symbol)
Synonyms	BRP44, DKFZP564B167
Description	Mitochondrial pyruvate carrier 2 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q24.2
Chromosome location (bp)	167916729 - 167937040
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143158 (version 83.38)
Entrez gene	25874
UniProt	O95563 (UniProt - Evidence at protein level)
neXtProt	NX_O95563
Antibodypedia	MPC2 antibodies

PROTEIN BROWSER

MPC2-001	MPC2-002	MPC2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPC2-001 ENSP00000356820 ENST00000367846	O95563 [Direct mapping] Mitochondrial pyruvate carrier 2 A0A024R8Z5 [Target identity:100%; Query identity:100%] Brain protein 44, isoform CRA_b Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006090 [pyruvate metabolic process] GO:0006850 [mitochondrial pyruvate transport] GO:0016021 [integral component of membrane] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0050833 [pyruvate transmembrane transporter activity] GO:0061732 [mitochondrial acetyl-CoA biosynthetic process from pyruvate] GO:1902361 [mitochondrial pyruvate transmembrane transport] Show all	127 aa 14.3 kDa	No	1
MPC2-002 ENSP00000271373 ENST00000271373	O95563 [Direct mapping] Mitochondrial pyruvate carrier 2 A0A024R8Z5 [Target identity:100%; Query identity:100%] Brain protein 44, isoform CRA_b Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006090 [pyruvate metabolic process] GO:0006850 [mitochondrial pyruvate transport] GO:0016021 [integral component of membrane] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] Show all	127 aa 14.3 kDa	No	1
MPC2-003 ENSP00000392874 ENST00000458574	Q5R3B4 [Direct mapping] Mitochondrial pyruvate carrier 2 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0006850 [mitochondrial pyruvate transport] Show all	105 aa 11.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.