Fields »
ABOUT
HELP
BLOG
UCK2

GENERAL INFORMATION

Gene name

 UCK2

Gene description

 Uridine-cytidine kinase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), lung cancer (unfavourable) and melanoma (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Lung cancer p<0.001
Melanoma p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 UCK2 (HGNC Symbol)

Synonyms

 UMPK

Description

 Uridine-cytidine kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]

Chromosome

 1

Cytoband

 q24.1

Chromosome location (bp)

 165827531 - 165911618

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143179 (version 83.38)

Entrez gene

 7371

UniProt

 Q9BZX2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BZX2

Antibodypedia

 UCK2 antibodies

PROTEIN BROWSER
UCK2-001
UCK2-005
UCK2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UCK2-001
ENSP00000356853
ENST00000367879
Q9BZX2 [Direct mapping]
Uridine-cytidine kinase 2
A0A024R912 [Target identity:100%; Query identity:100%]
Uridine-cytidine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004849 [uridine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006238 [CMP salvage]
GO:0008152 [metabolic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044206 [UMP salvage]
GO:0044211 [CTP salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 261 aa
29.3 kDa 		No 0
UCK2-005
ENSP00000476692
ENST00000469256
Q9BZX2 [Direct mapping]
Uridine-cytidine kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004849 [uridine kinase activity]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006238 [CMP salvage]
GO:0008152 [metabolic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044206 [UMP salvage]
GO:0044211 [CTP salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 111 aa
12.6 kDa 		No 0
UCK2-006
ENSP00000476327
ENST00000470820
Q9BZX2 [Direct mapping]
Uridine-cytidine kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004849 [uridine kinase activity]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006238 [CMP salvage]
GO:0008152 [metabolic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044206 [UMP salvage]
GO:0044211 [CTP salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 111 aa
12.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.