Tissue expression of TMCO1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TMCO1
Gene description	Transmembrane and coiled-coil domains 1
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TMCO1 (HGNC Symbol)
Synonyms	HP10122, TMCC4
Description	Transmembrane and coiled-coil domains 1 (HGNC Symbol)
Entrez gene summary	This locus encodes a transmembrane protein. Mutations at this locus have been associated with craniofacial dysmorphism, skeletal anomalies, and mental retardation. Mutations at this locus have also been associated with open angle glaucoma blindness. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
Chromosome	1
Cytoband	q24.1
Chromosome location (bp)	165724293 - 165827755
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143183 (version 83.38)
Entrez gene	54499
UniProt	Q9UM00 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UM00
Antibodypedia	TMCO1 antibodies

PROTEIN BROWSER

TMCO1-001	TMCO1-003	TMCO1-005	TMCO1-006	TMCO1-008	TMCO1-201	TMCO1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMCO1-001 ENSP00000356856 ENST00000367881	J9JIE6 [Direct mapping] Transmembrane and coiled-coil domain-containing protein 1; Transmembrane and coiled-coil domains 1, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	239 aa 27.1 kDa	No	3
TMCO1-003 ENSP00000462300 ENST00000481278	J3KS45 [Direct mapping] Transmembrane and coiled-coil domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	143 aa 16.6 kDa	No	1
TMCO1-005 ENSP00000463951 ENST00000464650	J3QQY2 [Direct mapping] Transmembrane and coiled-coil domain-containing protein 1; Transmembrane and coiled-coil domains 1, isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	104 aa 11.4 kDa	Yes	1
TMCO1-006 ENSP00000462588 ENST00000580248	J3QQY2 [Direct mapping] Transmembrane and coiled-coil domain-containing protein 1; Transmembrane and coiled-coil domains 1, isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	104 aa 11.4 kDa	Yes	1
TMCO1-008 ENSP00000375975 ENST00000392129	Q9UM00 [Direct mapping] Transmembrane and coiled-coil domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	188 aa 21.2 kDa	Yes	2
TMCO1-201 ENSP00000480514 ENST00000612311	J9JIE6 [Direct mapping] Transmembrane and coiled-coil domain-containing protein 1; Transmembrane and coiled-coil domains 1, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	239 aa 27.1 kDa	No	3
TMCO1-202 ENSP00000485789 ENST00000628579	J3KTQ7 [Direct mapping] Transmembrane and coiled-coil domain-containing protein 1; Transmembrane and coiled-coil domains 1, isoform CRA_d Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	152 aa 17.5 kDa	No	1