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RGS5

GENERAL INFORMATION

Gene name

 RGS5

Gene description

 Regulator of G-protein signaling 5

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (HUVEC TERT2, SH-SY5Y)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 RGS5

Synonyms

Description

 Regulator of G-protein signaling 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]

Chromosome

 1

Cytoband

 q23.3

Chromosome location (bp)

 163111121 - 163321791

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143248 (version 83.38)

Entrez gene

 8490

UniProt

 O15539 (UniProt - Evidence at protein level)

neXtProt

 NX_O15539

Antibodypedia

 RGS5 antibodies

PROTEIN BROWSER
RGS5-001
RGS5-002
RGS5-004
RGS5-006
RGS5-007
RGS5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RGS5-001
ENSP00000319308
ENST00000313961
O15539 [Direct mapping]
Regulator of G-protein signaling 5
A0A024R8X9 [Target identity:100%; Query identity:100%]
Regulator of G-protein signalling 5, isoform CRA_b
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Predicted intracellular proteins
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GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 181 aa
20.9 kDa 		No 0
RGS5-002
ENSP00000356879
ENST00000367903
B1APM2 [Direct mapping]
Regulator of G-protein signalling 5, isoform CRA_a; Regulator of G-protein-signaling 5
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Predicted intracellular proteins
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GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
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 201 aa
23.6 kDa 		No 0
RGS5-004
ENSP00000432313
ENST00000527988
O15539 [Direct mapping]
Regulator of G-protein signaling 5
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Predicted intracellular proteins
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 73 aa
8.7 kDa 		No 0
RGS5-006
ENSP00000433001
ENST00000530507
O15539 [Direct mapping]
Regulator of G-protein signaling 5
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Predicted intracellular proteins
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 185 aa
21.4 kDa 		No 0
RGS5-007
ENSP00000435861
ENST00000531476
E9PS96 [Direct mapping]
Regulator of G-protein-signaling 5
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Predicted intracellular proteins
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GO:0005886 [plasma membrane]
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 71 aa
8.2 kDa 		No 0
RGS5-201
ENSP00000480891
ENST00000618415
O15539 [Direct mapping]
Regulator of G-protein signaling 5
Show all
Predicted intracellular proteins
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 73 aa
8.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.