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SDHC

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GENERAL INFORMATION

Gene name

 SDHC

Gene description

 Succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa

Protein class

 Cancer-related genes
Citric acid cycle related proteins
Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SDHC (HGNC Symbol)

Synonyms

 CYB560, PGL3

Description

 Succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]

Chromosome

 1

Cytoband

 q23.3

Chromosome location (bp)

 161314257 - 161375340

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143252 (version 83.38)

Entrez gene

 6391

UniProt

 Q99643 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99643

Antibodypedia

 SDHC antibodies

PROTEIN BROWSER
SDHC-001
SDHC-003
SDHC-005
SDHC-006
SDHC-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SDHC-001
ENSP00000356953
ENST00000367975
Q99643 [Direct mapping]
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Citric acid cycle related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000104 [succinate dehydrogenase activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005749 [mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)]
GO:0006099 [tricarboxylic acid cycle]
GO:0006121 [mitochondrial electron transport, succinate to ubiquinone]
GO:0008177 [succinate dehydrogenase (ubiquinone) activity]
GO:0009055 [electron carrier activity]
GO:0009060 [aerobic respiration]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0020037 [heme binding]
GO:0022904 [respiratory electron transport chain]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045273 [respiratory chain complex II]
GO:0045281 [succinate dehydrogenase complex]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
Show all
 169 aa
18.6 kDa 		No 3
SDHC-003
ENSP00000356952
ENST00000342751
Q99643 [Direct mapping]
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000104 [succinate dehydrogenase activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005749 [mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)]
GO:0006099 [tricarboxylic acid cycle]
GO:0006121 [mitochondrial electron transport, succinate to ubiquinone]
GO:0008177 [succinate dehydrogenase (ubiquinone) activity]
GO:0009055 [electron carrier activity]
GO:0009060 [aerobic respiration]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0020037 [heme binding]
GO:0022904 [respiratory electron transport chain]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045273 [respiratory chain complex II]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
Show all
 150 aa
16.7 kDa 		No 0
SDHC-005
ENSP00000390558
ENST00000432287
Q99643 [Direct mapping]
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Citric acid cycle related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000104 [succinate dehydrogenase activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005749 [mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)]
GO:0006099 [tricarboxylic acid cycle]
GO:0006121 [mitochondrial electron transport, succinate to ubiquinone]
GO:0008177 [succinate dehydrogenase (ubiquinone) activity]
GO:0009055 [electron carrier activity]
GO:0009060 [aerobic respiration]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0020037 [heme binding]
GO:0022904 [respiratory electron transport chain]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045273 [respiratory chain complex II]
GO:0045281 [succinate dehydrogenase complex]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
Show all
 135 aa
14.8 kDa 		No 3
SDHC-006
ENSP00000376009
ENST00000392169
Q99643 [Direct mapping]
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Citric acid cycle related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000104 [succinate dehydrogenase activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005749 [mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)]
GO:0006099 [tricarboxylic acid cycle]
GO:0006121 [mitochondrial electron transport, succinate to ubiquinone]
GO:0008177 [succinate dehydrogenase (ubiquinone) activity]
GO:0009055 [electron carrier activity]
GO:0009060 [aerobic respiration]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0020037 [heme binding]
GO:0022904 [respiratory electron transport chain]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045273 [respiratory chain complex II]
GO:0045281 [succinate dehydrogenase complex]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
Show all
 116 aa
12.5 kDa 		Yes 3
SDHC-007
ENSP00000423260
ENST00000513009
Q99643 [Direct mapping]
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005749 [mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)]
GO:0006099 [tricarboxylic acid cycle]
GO:0006121 [mitochondrial electron transport, succinate to ubiquinone]
GO:0008177 [succinate dehydrogenase (ubiquinone) activity]
GO:0009055 [electron carrier activity]
GO:0009060 [aerobic respiration]
GO:0016021 [integral component of membrane]
GO:0020037 [heme binding]
GO:0022904 [respiratory electron transport chain]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045273 [respiratory chain complex II]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
Show all
 116 aa
12.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.