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NR1I3

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GENERAL INFORMATION

Gene name

 NR1I3

Gene description

 Nuclear receptor subfamily 1, group I, member 3

Protein class

 Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 24
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (CACO-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA051365
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CACO-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA051365 HeLa No staining    
HPA051365 MCF7 Nucleoplasm
HPA051365 U-2 OS No staining    

GENE INFORMATION

Gene name

 NR1I3 (HGNC Symbol)

Synonyms

 CAR, CAR1, MB67

Description

 Nuclear receptor subfamily 1, group I, member 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q23.3

Chromosome location (bp)

 161229666 - 161238302

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143257 (version 83.38)

Entrez gene

 9970

UniProt

 Q14994 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14994

Antibodypedia

 NR1I3 antibodies

PROTEIN BROWSER
«
NR1I3-001
NR1I3-002
NR1I3-008
NR1I3-009
NR1I3-011
NR1I3-012
NR1I3-013
NR1I3-014
NR1I3-015
NR1I3-016
NR1I3-019
NR1I3-021
NR1I3-024
NR1I3-025
NR1I3-026
NR1I3-027
NR1I3-029
NR1I3-030
NR1I3-031
NR1I3-032
NR1I3-033
NR1I3-036
NR1I3-201
NR1I3-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR1I3-001
ENSP00000356962
ENST00000367983
Q14994 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 348 aa
39.6 kDa 		No 0
NR1I3-002
ENSP00000356961
ENST00000367982
Q14994 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 352 aa
39.9 kDa 		No 0
NR1I3-008
ENSP00000427034
ENST00000515452
B7Z8R7 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3; cDNA FLJ56764, highly similar to Orphan nuclear receptor NR1I3; cDNA, FLJ79107, highly similar to Orphan nuclear receptor NR1I3
Show all
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 238 aa
26.8 kDa 		No 0
NR1I3-009
ENSP00000423089
ENST00000506209
E9PCF2 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 297 aa
34 kDa 		No 0
NR1I3-011
ENSP00000356963
ENST00000367984
Q14994 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 309 aa
35 kDa 		No 0
NR1I3-012
ENSP00000356965
ENST00000367985
Q14994 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 314 aa
35.6 kDa 		No 0
NR1I3-013
ENSP00000422982
ENST00000508387
Q6GZ70 [Direct mapping]
Constitutive androstane receptor SV19; Constitutive androstane receptor SV20; Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 118 aa
13.5 kDa 		No 0
NR1I3-014
ENSP00000424345
ENST00000504010
Q14994 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 280 aa
31.9 kDa 		No 0
NR1I3-015
ENSP00000427175
ENST00000511676
Q14994 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 319 aa
36.4 kDa 		No 0
NR1I3-016
ENSP00000421374
ENST00000502985
Q6GZ72 [Direct mapping]
Constitutive androstane receptor SV17; Constitutive androstane receptor SV18; Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043565 [sequence-specific DNA binding]
Show all
 147 aa
16.6 kDa 		No 0
NR1I3-019
ENSP00000356960
ENST00000367981
Q14994 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 324 aa
37 kDa 		No 0
NR1I3-021
ENSP00000421588
ENST00000515621
D6REZ7 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
Show all
 273 aa
31.4 kDa 		No 0
NR1I3-024
ENSP00000425417
ENST00000512372
Q14994 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 267 aa
30.3 kDa 		No 0
NR1I3-025
ENSP00000407446
ENST00000437437
Q14994 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 306 aa
34.8 kDa 		No 0
NR1I3-026
ENSP00000426292
ENST00000511944
Q6GZ72 [Direct mapping]
Constitutive androstane receptor SV17; Constitutive androstane receptor SV18; Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043565 [sequence-specific DNA binding]
Show all
 147 aa
16.6 kDa 		No 0
NR1I3-027
ENSP00000427600
ENST00000511748
Q6GZ70 [Direct mapping]
Constitutive androstane receptor SV19; Constitutive androstane receptor SV20; Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 118 aa
13.5 kDa 		No 0
NR1I3-029
ENSP00000406493
ENST00000442691
Q14994 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 339 aa
38.3 kDa 		No 0
NR1I3-030
ENSP00000399361
ENST00000412844
Q14994 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 315 aa
35.7 kDa 		No 0
NR1I3-031
ENSP00000412672
ENST00000428574
Q14994 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 340 aa
38.5 kDa 		No 0
NR1I3-032
ENSP00000424934
ENST00000505005
Q14994 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 296 aa
33.4 kDa 		No 0
NR1I3-033
ENSP00000423666
ENST00000508740
Q14994 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 311 aa
35.3 kDa 		No 0
NR1I3-036
ENSP00000356958
ENST00000367979
Q14994 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 357 aa
40.5 kDa 		No 0
NR1I3-201
ENSP00000356959
ENST00000367980
Q14994 [Direct mapping]
Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001649 [osteoblast differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 357 aa
40.5 kDa 		No 0
NR1I3-202
ENSP00000487337
ENST00000628566
Q6GZ69 [Direct mapping]
Constitutive androstane receptor SV21; Nuclear receptor subfamily 1 group I member 3
Show all
Nuclear receptors
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043565 [sequence-specific DNA binding]
Show all
 119 aa
12.9 kDa 		No 0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.