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USP21

GENERAL INFORMATION

Gene name

 USP21

Gene description

 Ubiquitin specific peptidase 21

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA028397
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (favourable), liver cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Liver cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028397

GENE INFORMATION

Gene name

 USP21 (HGNC Symbol)

Synonyms

 USP16, USP23

Description

 Ubiquitin specific peptidase 21 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q23.3

Chromosome location (bp)

 161159450 - 161165723

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143258 (version 83.38)

Entrez gene

 27005

UniProt

 Q9UK80 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UK80

Antibodypedia

 USP21 antibodies

PROTEIN BROWSER
USP21-001
USP21-002
USP21-004
USP21-005
USP21-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USP21-001
ENSP00000289865
ENST00000289865
Q9UK80 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 21
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Show all
GO:0003713 [transcription coactivator activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0016578 [histone deubiquitination]
GO:0016579 [protein deubiquitination]
GO:0019784 [NEDD8-specific protease activity]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
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 565 aa
62.7 kDa 		No 0
USP21-002
ENSP00000356980
ENST00000368001
Q9UK80 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 21
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Show all
GO:0003713 [transcription coactivator activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0016578 [histone deubiquitination]
GO:0016579 [protein deubiquitination]
GO:0019784 [NEDD8-specific protease activity]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 551 aa
61.1 kDa 		No 0
USP21-004
ENSP00000476344
ENST00000492950
V9GY36 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 21
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Predicted intracellular proteins
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016578 [histone deubiquitination]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 253 aa
27.4 kDa 		No 0
USP21-005
ENSP00000476830
ENST00000479344
V9GYJ6 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 21
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Predicted intracellular proteins
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016578 [histone deubiquitination]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 117 aa
12.6 kDa 		No 0
USP21-201
ENSP00000356981
ENST00000368002
Q9UK80 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 21
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Show all
GO:0003713 [transcription coactivator activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0016578 [histone deubiquitination]
GO:0016579 [protein deubiquitination]
GO:0019784 [NEDD8-specific protease activity]
GO:0031175 [neuron projection development]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 565 aa
62.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.