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This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Q96RD9 [Direct mapping] Fc receptor-like protein 5
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CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0043235 [receptor complex] GO:0050859 [negative regulation of B cell receptor signaling pathway] GO:0051280 [negative regulation of release of sequestered calcium ion into cytosol]
