Expression of RRNAD1 in cancer - Summary - The Human Protein Atlas

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RRNAD1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RRNAD1
Gene description	Ribosomal RNA adenine dimethylase domain containing 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Mainly nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA047426
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable).
Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047426

GENE INFORMATION
Gene name	RRNAD1 (HGNC Symbol)
Synonyms	C1orf66, CGI-41
Description	Ribosomal RNA adenine dimethylase domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q23.1
Chromosome location (bp)	156728442 - 156736960
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000143303 (version 83.38)
Entrez gene	51093
UniProt	Q96FB5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96FB5
Antibodypedia	RRNAD1 antibodies

PROTEIN BROWSER

RRNAD1-001	RRNAD1-002	RRNAD1-003	RRNAD1-007	RRNAD1-008	RRNAD1-009	RRNAD1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RRNAD1-001 ENSP00000357199 ENST00000368216	Q96FB5 [Direct mapping] Protein RRNAD1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000154 [rRNA modification] GO:0000179 [rRNA (adenine-N6,N6-)-dimethyltransferase activity] GO:0008649 [rRNA methyltransferase activity] GO:0016021 [integral component of membrane] GO:0031167 [rRNA methylation] Show all	475 aa 53 kDa	No	1
RRNAD1-002 ENSP00000429053 ENST00000484742	E5RJL6 [Direct mapping] Protein RRNAD1 Show all	Predicted intracellular proteins Show all	GO:0000154 [rRNA modification] GO:0000179 [rRNA (adenine-N6,N6-)-dimethyltransferase activity] GO:0008649 [rRNA methyltransferase activity] GO:0031167 [rRNA methylation] Show all	101 aa 11.4 kDa	No	0
RRNAD1-003 ENSP00000430787 ENST00000476229	E5RI42 [Direct mapping] Protein RRNAD1 Show all	Predicted intracellular proteins Show all		154 aa 16.2 kDa	No	0
RRNAD1-007 ENSP00000357201 ENST00000368218	Q96FB5 [Direct mapping] Protein RRNAD1 Show all	Predicted intracellular proteins Show all	GO:0000154 [rRNA modification] GO:0000179 [rRNA (adenine-N6,N6-)-dimethyltransferase activity] GO:0008649 [rRNA methyltransferase activity] GO:0016021 [integral component of membrane] GO:0031167 [rRNA methylation] Show all	277 aa 29.7 kDa	No	0
RRNAD1-008 ENSP00000429389 ENST00000524343	E5RIL6 [Direct mapping] Protein RRNAD1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all		94 aa 10 kDa	No	0
RRNAD1-009 ENSP00000429756 ENST00000519086	E5RHI7 [Direct mapping] Protein RRNAD1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all		345 aa 38.7 kDa	No	0
RRNAD1-011 ENSP00000429800 ENST00000522237	H0YBL9 [Direct mapping] Protein RRNAD1 Show all	Predicted intracellular proteins Show all	GO:0000154 [rRNA modification] GO:0000179 [rRNA (adenine-N6,N6-)-dimethyltransferase activity] GO:0008649 [rRNA methyltransferase activity] GO:0031167 [rRNA methylation] Show all	139 aa 15.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.