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CRABP2

GENERAL INFORMATION

Gene name

 CRABP2

Gene description

 Cellular retinoic acid binding protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (esophagus)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (cervix, uterine, esophagus)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in squamous epithelia. Additional cytoplasmic expression in salivary and breast glands.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA004135
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine, esophagus)

GENE INFORMATION

Gene name

 CRABP2 (HGNC Symbol)

Synonyms

 CRABP-II

Description

 Cellular retinoic acid binding protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]

Chromosome

 1

Cytoband

 q23.1

Chromosome location (bp)

 156699606 - 156705816

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143320 (version 83.38)

Entrez gene

 1382

UniProt

 P29373 (UniProt - Evidence at protein level)

neXtProt

 NX_P29373

Antibodypedia

 CRABP2 antibodies

PROTEIN BROWSER
CRABP2-001
CRABP2-002
CRABP2-003
CRABP2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRABP2-001
ENSP00000357205
ENST00000368222
P29373 [Direct mapping]
Cellular retinoic acid-binding protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005501 [retinoid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0007165 [signal transduction]
GO:0008289 [lipid binding]
GO:0008544 [epidermis development]
GO:0016918 [retinal binding]
GO:0019841 [retinol binding]
GO:0048385 [regulation of retinoic acid receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 138 aa
15.7 kDa 		No 0
CRABP2-002
ENSP00000357203
ENST00000368220
Q5SYZ4 [Direct mapping]
Cellular retinoic acid-binding protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001972 [retinoic acid binding]
GO:0005215 [transporter activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0048385 [regulation of retinoic acid receptor signaling pathway]
Show all
 82 aa
9.3 kDa 		No 0
CRABP2-003
ENSP00000357204
ENST00000368221
P29373 [Direct mapping]
Cellular retinoic acid-binding protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005501 [retinoid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0007165 [signal transduction]
GO:0008289 [lipid binding]
GO:0008544 [epidermis development]
GO:0016918 [retinal binding]
GO:0019841 [retinol binding]
GO:0048385 [regulation of retinoic acid receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 138 aa
15.7 kDa 		No 0
CRABP2-201
ENSP00000482841
ENST00000621784
P29373 [Direct mapping]
Cellular retinoic acid-binding protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001972 [retinoic acid binding]
GO:0005215 [transporter activity]
GO:0005501 [retinoid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0007165 [signal transduction]
GO:0008289 [lipid binding]
GO:0008544 [epidermis development]
GO:0016918 [retinal binding]
GO:0019841 [retinol binding]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0042573 [retinoic acid metabolic process]
GO:0048385 [regulation of retinoic acid receptor signaling pathway]
GO:0048672 [positive regulation of collateral sprouting]
GO:0070062 [extracellular exosome]
Show all
 138 aa
15.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.