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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expressioni
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Caution, splice and/or transcript discrepancy exists and external data suggests several subcellular locations.
Reliability scorei
Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page. Images of selected tissues give a visual summary of the protein expression profile furthest to the right. The gray human body provides links to a histology dictionary when clicking on any part of the figure.
RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.
Protein expression data is shown for each of the 44 tissues. The color-coding is based on tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Organ
Expression
Alphabetical
RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
HPA dataseti
HPA dataset RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.
RNA tissue category HPA HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataseti
GTEx dataset RNA-seq data are reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.
RNA tissue category GTEx GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataseti
FANTOM5 dataset Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.
RNA tissue category FANTOM5 FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
ABL2-001
ABL2-002
ABL2-005
ABL2-006
ABL2-007
ABL2-008
ABL2-009
ABL2-010
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0001891 [phagocytic cup] GO:0003785 [actin monomer binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006909 [phagocytosis] GO:0006930 [substrate-dependent cell migration, cell extension] GO:0007015 [actin filament organization] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0007612 [learning] GO:0008542 [visual learning] GO:0010506 [regulation of autophagy] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0015629 [actin cytoskeleton] GO:0016322 [neuron remodeling] GO:0016477 [cell migration] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0021587 [cerebellum morphogenesis] GO:0022408 [negative regulation of cell-cell adhesion] GO:0030027 [lamellipodium] GO:0030100 [regulation of endocytosis] GO:0030145 [manganese ion binding] GO:0030154 [cell differentiation] GO:0030155 [regulation of cell adhesion] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032092 [positive regulation of protein binding] GO:0034613 [cellular protein localization] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0035640 [exploration behavior] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043197 [dendritic spine] GO:0045087 [innate immune response] GO:0046632 [alpha-beta T cell differentiation] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048813 [dendrite morphogenesis] GO:0050885 [neuromuscular process controlling balance] GO:0051015 [actin filament binding] GO:0051017 [actin filament bundle assembly] GO:0051353 [positive regulation of oxidoreductase activity] GO:0060020 [Bergmann glial cell differentiation] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071300 [cellular response to retinoic acid] GO:0097062 [dendritic spine maintenance] GO:1900042 [positive regulation of interleukin-2 secretion] GO:1902715 [positive regulation of interferon-gamma secretion] GO:1903053 [regulation of extracellular matrix organization] GO:2000096 [positive regulation of Wnt signaling pathway, planar cell polarity pathway] GO:2000145 [regulation of cell motility] GO:2000249 [regulation of actin cytoskeleton reorganization] GO:2000352 [negative regulation of endothelial cell apoptotic process]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding] GO:0003785 [actin monomer binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0010506 [regulation of autophagy] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0015629 [actin cytoskeleton] GO:0016477 [cell migration] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030100 [regulation of endocytosis] GO:0030145 [manganese ion binding] GO:0030154 [cell differentiation] GO:0030155 [regulation of cell adhesion] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0045087 [innate immune response] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0051015 [actin filament binding] GO:0051353 [positive regulation of oxidoreductase activity] GO:0071300 [cellular response to retinoic acid] GO:2000145 [regulation of cell motility] GO:2000249 [regulation of actin cytoskeleton reorganization]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding] GO:0003785 [actin monomer binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0010506 [regulation of autophagy] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0015629 [actin cytoskeleton] GO:0016477 [cell migration] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030100 [regulation of endocytosis] GO:0030145 [manganese ion binding] GO:0030154 [cell differentiation] GO:0030155 [regulation of cell adhesion] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0045087 [innate immune response] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0051015 [actin filament binding] GO:0051353 [positive regulation of oxidoreductase activity] GO:0071300 [cellular response to retinoic acid] GO:2000145 [regulation of cell motility] GO:2000249 [regulation of actin cytoskeleton reorganization]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding] GO:0003785 [actin monomer binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0010506 [regulation of autophagy] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0015629 [actin cytoskeleton] GO:0016477 [cell migration] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030100 [regulation of endocytosis] GO:0030145 [manganese ion binding] GO:0030154 [cell differentiation] GO:0030155 [regulation of cell adhesion] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0045087 [innate immune response] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0051015 [actin filament binding] GO:0051353 [positive regulation of oxidoreductase activity] GO:0071300 [cellular response to retinoic acid] GO:2000145 [regulation of cell motility] GO:2000249 [regulation of actin cytoskeleton reorganization]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding] GO:0003785 [actin monomer binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0010506 [regulation of autophagy] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0015629 [actin cytoskeleton] GO:0016477 [cell migration] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030100 [regulation of endocytosis] GO:0030145 [manganese ion binding] GO:0030154 [cell differentiation] GO:0030155 [regulation of cell adhesion] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0045087 [innate immune response] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0051015 [actin filament binding] GO:0051353 [positive regulation of oxidoreductase activity] GO:0071300 [cellular response to retinoic acid] GO:2000145 [regulation of cell motility] GO:2000249 [regulation of actin cytoskeleton reorganization]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding] GO:0003785 [actin monomer binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0010506 [regulation of autophagy] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0015629 [actin cytoskeleton] GO:0016477 [cell migration] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030100 [regulation of endocytosis] GO:0030145 [manganese ion binding] GO:0030154 [cell differentiation] GO:0030155 [regulation of cell adhesion] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0045087 [innate immune response] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0051015 [actin filament binding] GO:0051353 [positive regulation of oxidoreductase activity] GO:0071300 [cellular response to retinoic acid] GO:2000145 [regulation of cell motility] GO:2000249 [regulation of actin cytoskeleton reorganization]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding] GO:0003785 [actin monomer binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0010506 [regulation of autophagy] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0015629 [actin cytoskeleton] GO:0016477 [cell migration] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030100 [regulation of endocytosis] GO:0030145 [manganese ion binding] GO:0030154 [cell differentiation] GO:0030155 [regulation of cell adhesion] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0045087 [innate immune response] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0051015 [actin filament binding] GO:0051353 [positive regulation of oxidoreductase activity] GO:0071300 [cellular response to retinoic acid] GO:2000145 [regulation of cell motility] GO:2000249 [regulation of actin cytoskeleton reorganization]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding] GO:0003785 [actin monomer binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0010506 [regulation of autophagy] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0015629 [actin cytoskeleton] GO:0016477 [cell migration] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030100 [regulation of endocytosis] GO:0030145 [manganese ion binding] GO:0030154 [cell differentiation] GO:0030155 [regulation of cell adhesion] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0045087 [innate immune response] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0051015 [actin filament binding] GO:0051353 [positive regulation of oxidoreductase activity] GO:0071300 [cellular response to retinoic acid] GO:2000145 [regulation of cell motility] GO:2000249 [regulation of actin cytoskeleton reorganization]
