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RGL1

GENERAL INFORMATION

Gene name

 RGL1

Gene description

 Ral guanine nucleotide dissociation stimulator-like 1

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA019788
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and lung cancer (favourable).
Liver cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019788

GENE INFORMATION

Gene name

 RGL1 (HGNC Symbol)

Synonyms

 RGL

Description

 Ral guanine nucleotide dissociation stimulator-like 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 q25.3

Chromosome location (bp)

 183636085 - 183928531

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143344 (version 83.38)

Entrez gene

 23179

UniProt

 Q9NZL6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZL6

Antibodypedia

 RGL1 antibodies

PROTEIN BROWSER
RGL1-001
RGL1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RGL1-001
ENSP00000303192
ENST00000304685
Q9NZL6 [Direct mapping]
Ral guanine nucleotide dissociation stimulator-like 1
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
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GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008321 [Ral guanyl-nucleotide exchange factor activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
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 803 aa
90.7 kDa 		No 0
RGL1-002
ENSP00000354097
ENST00000360851
Q9NZL6 [Direct mapping]
Ral guanine nucleotide dissociation stimulator-like 1
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008321 [Ral guanyl-nucleotide exchange factor activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
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 768 aa
86.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.