Expression of PRUNE in cancer - Summary - The Human Protein Atlas

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PRUNE

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PRUNE
Gene description	Prune exopolyphosphatase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membrane expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA028411
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028411

GENE INFORMATION
Gene name	PRUNE (HGNC Symbol)
Synonyms	DRES-17, HTCD37
Description	Prune exopolyphosphatase (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	151008420 - 151035713
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143363 (version 83.38)
Entrez gene	58497
UniProt	Q86TP1 (UniProt - Evidence at protein level)
neXtProt	NX_Q86TP1
Antibodypedia	PRUNE antibodies

PROTEIN BROWSER

PRUNE-001	PRUNE-002	PRUNE-003	PRUNE-004	PRUNE-005	PRUNE-009	PRUNE-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRUNE-001 ENSP00000271620 ENST00000271620	Q86TP1 [Direct mapping] Protein prune homolog Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004309 [exopolyphosphatase activity] GO:0004427 [inorganic diphosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0006798 [polyphosphate catabolic process] GO:0016462 [pyrophosphatase activity] GO:0046872 [metal ion binding] Show all	453 aa 50.2 kDa	No	0
PRUNE-002 ENSP00000357933 ENST00000368937	Q86TP1 [Direct mapping] Protein prune homolog Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004309 [exopolyphosphatase activity] GO:0004427 [inorganic diphosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0006798 [polyphosphate catabolic process] GO:0016462 [pyrophosphatase activity] GO:0046872 [metal ion binding] Show all	218 aa 24.1 kDa	No	0
PRUNE-003 ENSP00000357932 ENST00000368936	Q86TP1 [Direct mapping] Protein prune homolog Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004309 [exopolyphosphatase activity] GO:0004427 [inorganic diphosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0006798 [polyphosphate catabolic process] GO:0016462 [pyrophosphatase activity] GO:0046872 [metal ion binding] Show all	271 aa 30.1 kDa	No	0
PRUNE-004 ENSP00000357930 ENST00000368934	Q86TP1 [Direct mapping] Protein prune homolog Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004309 [exopolyphosphatase activity] GO:0004427 [inorganic diphosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0006798 [polyphosphate catabolic process] GO:0016462 [pyrophosphatase activity] GO:0046872 [metal ion binding] Show all	218 aa 24.1 kDa	No	0
PRUNE-005 ENSP00000357931 ENST00000368935	Q86TP1 [Direct mapping] Protein prune homolog Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004309 [exopolyphosphatase activity] GO:0004427 [inorganic diphosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0006798 [polyphosphate catabolic process] GO:0046872 [metal ion binding] Show all	168 aa 18.5 kDa	No	0
PRUNE-009 ENSP00000392632 ENST00000431193	Q5SZG1 [Direct mapping] Protein prune homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004309 [exopolyphosphatase activity] GO:0005737 [cytoplasm] GO:0006798 [polyphosphate catabolic process] GO:0016462 [pyrophosphatase activity] Show all	178 aa 19.9 kDa	No	0
PRUNE-010 ENSP00000387696 ENST00000450884	Q5SZF2 [Direct mapping] Protein prune homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004309 [exopolyphosphatase activity] GO:0005737 [cytoplasm] GO:0006798 [polyphosphate catabolic process] GO:0016462 [pyrophosphatase activity] Show all	140 aa 16 kDa	No	0

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The Human Protein Atlas

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