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RORC

GENERAL INFORMATION

Gene name

 RORC

Gene description

 RAR-related orphan receptor C

Protein class

 Disease related genes
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (skeletal muscle)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)

GENE INFORMATION

Gene name

 RORC (HGNC Symbol)

Synonyms

 NR1F3, RORG, RZRG, TOR

Description

 RAR-related orphan receptor C (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 151806071 - 151831872

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143365 (version 83.38)

Entrez gene

 6097

UniProt

 P51449 (UniProt - Evidence at protein level)

neXtProt

 NX_P51449

Antibodypedia

 RORC antibodies

PROTEIN BROWSER
RORC-001
RORC-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RORC-001
ENSP00000327025
ENST00000318247
P51449 [Direct mapping]
Nuclear receptor ROR-gamma
Q6I9R9 [Target identity:100%; Query identity:100%]
RAR-related orphan receptor C; RORC protein
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006805 [xenobiotic metabolic process]
GO:0007623 [circadian rhythm]
GO:0008142 [oxysterol binding]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010906 [regulation of glucose metabolic process]
GO:0019218 [regulation of steroid metabolic process]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032922 [circadian regulation of gene expression]
GO:0036315 [cellular response to sterol]
GO:0042093 [T-helper cell differentiation]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045598 [regulation of fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048535 [lymph node development]
GO:0048541 [Peyer's patch development]
GO:0060612 [adipose tissue development]
GO:0060850 [regulation of transcription involved in cell fate commitment]
GO:0070244 [negative regulation of thymocyte apoptotic process]
GO:0072539 [T-helper 17 cell differentiation]
GO:0098531 [transcription factor activity, direct ligand regulated sequence-specific DNA binding]
Show all
 518 aa
58.2 kDa 		No 0
RORC-002
ENSP00000349164
ENST00000356728
P51449 [Direct mapping]
Nuclear receptor ROR-gamma
F1D8P6 [Target identity:100%; Query identity:100%]
RAR-related orphan nuclear receptor variant 2
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006805 [xenobiotic metabolic process]
GO:0008142 [oxysterol binding]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010906 [regulation of glucose metabolic process]
GO:0019218 [regulation of steroid metabolic process]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032922 [circadian regulation of gene expression]
GO:0036315 [cellular response to sterol]
GO:0042093 [T-helper cell differentiation]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045598 [regulation of fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048535 [lymph node development]
GO:0048541 [Peyer's patch development]
GO:0060612 [adipose tissue development]
GO:0060850 [regulation of transcription involved in cell fate commitment]
GO:0070244 [negative regulation of thymocyte apoptotic process]
GO:0072539 [T-helper 17 cell differentiation]
GO:0098531 [transcription factor activity, direct ligand regulated sequence-specific DNA binding]
Show all
 497 aa
55.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.