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SF3B4

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GENERAL INFORMATION

Gene name

 SF3B4

Gene description

 Splicing factor 3b, subunit 4, 49kDa

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nuclear speckles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA064660
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nuclear speckles.

Main location

 Nuclear speckles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA064660 MCF7 Nuclear speckles
HPA064660 U-2 OS Nuclear speckles
HPA064660 U-251 MG Nuclear speckles

GENE INFORMATION

Gene name

 SF3B4 (HGNC Symbol)

Synonyms

 Hsh49, SAP49, SF3b49

Description

 Splicing factor 3b, subunit 4, 49kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q21.2

Chromosome location (bp)

 149923317 - 149928344

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143368 (version 83.38)

Entrez gene

 10262

UniProt

 Q15427 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15427

Antibodypedia

 SF3B4 antibodies

PROTEIN BROWSER
SF3B4-001
SF3B4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SF3B4-001
ENSP00000271628
ENST00000271628
Q15427 [Direct mapping]
Splicing factor 3B subunit 4
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005689 [U12-type spliceosomal complex]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0044822 [poly(A) RNA binding]
GO:0048026 [positive regulation of mRNA splicing, via spliceosome]
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 424 aa
44.4 kDa 		No 0
SF3B4-002
ENSP00000391114
ENST00000457312
Q5SZ64 [Direct mapping]
Splicing factor 3B subunit 4; Splicing factor 3b, subunit 4, 49kDa
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 190 aa
20.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.