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ECM1

GENERAL INFORMATION

Gene name

 ECM1

Gene description

 Extracellular matrix protein 1

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (epididymis, esophagus)
GTEx:Expressed in all
FANTOM5:Group enriched (epididymis, esophagus, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in squamous epithelia and in glandular cells of epididymis.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA027241
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (epididymis, esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (epididymis, esophagus, tonsil)

GENE INFORMATION

Gene name

 ECM1

Synonyms

Description

 Extracellular matrix protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Chromosome

 1

Cytoband

 q21.2

Chromosome location (bp)

 150508062 - 150513789

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143369 (version 83.38)

Entrez gene

 1893

UniProt

 Q16610 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16610

Antibodypedia

 ECM1 antibodies

PROTEIN BROWSER
ECM1-011
ECM1-012
ECM1-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ECM1-011
ENSP00000358043
ENST00000369047
Q16610 [Direct mapping]
Extracellular matrix protein 1
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0001525 [angiogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002020 [protease binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0007165 [signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0010466 [negative regulation of peptidase activity]
GO:0019899 [enzyme binding]
GO:0030502 [negative regulation of bone mineralization]
GO:0031012 [extracellular matrix]
GO:0031214 [biomineral tissue development]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043236 [laminin binding]
GO:0045766 [positive regulation of angiogenesis]
GO:0070062 [extracellular exosome]
Show all
 540 aa
60.7 kDa 		Yes 0
ECM1-012
ENSP00000358045
ENST00000369049
Q16610 [Direct mapping]
Extracellular matrix protein 1
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0001525 [angiogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001960 [negative regulation of cytokine-mediated signaling pathway]
GO:0002020 [protease binding]
GO:0002828 [regulation of type 2 immune response]
GO:0004871 [signal transducer activity]
GO:0005134 [interleukin-2 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0010466 [negative regulation of peptidase activity]
GO:0019899 [enzyme binding]
GO:0030502 [negative regulation of bone mineralization]
GO:0031012 [extracellular matrix]
GO:0031214 [biomineral tissue development]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043236 [laminin binding]
GO:0045766 [positive regulation of angiogenesis]
GO:0070062 [extracellular exosome]
GO:2000404 [regulation of T cell migration]
Show all
 567 aa
63.6 kDa 		Yes 0
ECM1-013
ENSP00000271630
ENST00000346569
Q16610 [Direct mapping]
Extracellular matrix protein 1
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0001525 [angiogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002020 [protease binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0007165 [signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0010466 [negative regulation of peptidase activity]
GO:0019899 [enzyme binding]
GO:0030502 [negative regulation of bone mineralization]
GO:0031012 [extracellular matrix]
GO:0031214 [biomineral tissue development]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043236 [laminin binding]
GO:0045766 [positive regulation of angiogenesis]
GO:0070062 [extracellular exosome]
Show all
 415 aa
46.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.