Expression of SETDB1 in cancer - Summary - The Human Protein Atlas

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SETDB1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SETDB1
Gene description	SET domain, bifurcated 1
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA018142
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018142

GENE INFORMATION
Gene name	SETDB1 (HGNC Symbol)
Synonyms	ESET, KG1T, KIAA0067, KMT1E, TDRD21
Description	SET domain, bifurcated 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	150926263 - 150964744
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143379 (version 83.38)
Entrez gene	9869
UniProt	Q15047 (UniProt - Evidence at protein level)
neXtProt	NX_Q15047
Antibodypedia	SETDB1 antibodies

PROTEIN BROWSER

SETDB1-001	SETDB1-002	SETDB1-005	SETDB1-006	SETDB1-008	SETDB1-009	SETDB1-012	SETDB1-013	SETDB1-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SETDB1-001 ENSP00000271640 ENST00000271640	Q15047 [Direct mapping] Histone-lysine N-methyltransferase SETDB1 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0001833 [inner cell mass cell proliferation] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0033273 [response to vitamin] GO:0034968 [histone lysine methylation] GO:0036124 [histone H3-K9 trimethylation] GO:0043231 [intracellular membrane-bounded organelle] GO:0045471 [response to ethanol] GO:0060348 [bone development] Show all	1291 aa 143.2 kDa	No	0
SETDB1-002 ENSP00000357958 ENST00000368962	Q15047 [Direct mapping] Histone-lysine N-methyltransferase SETDB1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0043231 [intracellular membrane-bounded organelle] Show all	397 aa 44.7 kDa	No	1
SETDB1-005 ENSP00000432348 ENST00000498193	E9PRF4 [Direct mapping] Histone-lysine N-methyltransferase SETDB1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008270 [zinc ion binding] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] GO:0043231 [intracellular membrane-bounded organelle] Show all	1259 aa 139.4 kDa	No	0
SETDB1-006 ENSP00000435922 ENST00000525956	E9PS59 [Direct mapping] Histone-lysine N-methyltransferase SETDB1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		163 aa 18.2 kDa	No	0
SETDB1-008 ENSP00000407831 ENST00000423081	X6RHV1 [Direct mapping] Histone-lysine N-methyltransferase SETDB1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		151 aa 17.1 kDa	No	0
SETDB1-009 ENSP00000357959 ENST00000368963	X6R732 [Direct mapping] Histone-lysine N-methyltransferase SETDB1 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		249 aa 27.7 kDa	No	0
SETDB1-012 ENSP00000409379 ENST00000448029	B0QZE6 [Direct mapping] Histone-lysine N-methyltransferase SETDB1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		156 aa 17.4 kDa	No	0
SETDB1-013 ENSP00000436148 ENST00000534805	E9PQM8 [Direct mapping] Histone-lysine N-methyltransferase SETDB1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	636 aa 71 kDa	No	0
SETDB1-014 ENSP00000357965 ENST00000368969	Q15047 [Direct mapping] Histone-lysine N-methyltransferase SETDB1 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] GO:0043231 [intracellular membrane-bounded organelle] Show all	1290 aa 143 kDa	No	0

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