Tissue expression of ADAMTSL4 - Summary - The Human Protein Atlas

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ADAMTSL4

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ADAMTSL4
Gene description	ADAMTS-like 4
Protein class	Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (placenta)
GTEx:	Expressed in all
FANTOM5:	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA006279
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION
Gene name	ADAMTSL4 (HGNC Symbol)
Synonyms	DKFZP434K1772, TSRC1
Description	ADAMTS-like 4 (HGNC Symbol)
Entrez gene summary	This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Sep 2014]
Chromosome	1
Cytoband	q21.2
Chromosome location (bp)	150549369 - 150560937
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143382 (version 83.38)
Entrez gene	54507
UniProt	Q6UY14 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UY14
Antibodypedia	ADAMTSL4 antibodies

PROTEIN BROWSER

ADAMTSL4-001	ADAMTSL4-002	ADAMTSL4-201	ADAMTSL4-202	ADAMTSL4-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTSL4-001 ENSP00000358034 ENST00000369038	Q6UY14 [Direct mapping] ADAMTS-like protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0008233 [peptidase activity] GO:0031012 [extracellular matrix] GO:0036066 [protein O-linked fucosylation] GO:0043065 [positive regulation of apoptotic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	1074 aa 116.5 kDa	Yes	0
ADAMTSL4-002 ENSP00000358037 ENST00000369041	Q6UY14 [Direct mapping] ADAMTS-like protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0031012 [extracellular matrix] GO:0036066 [protein O-linked fucosylation] GO:0043065 [positive regulation of apoptotic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	877 aa 95.1 kDa	Yes	0
ADAMTSL4-201 ENSP00000271643 ENST00000271643	Q6UY14 [Direct mapping] ADAMTS-like protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0008233 [peptidase activity] GO:0031012 [extracellular matrix] GO:0036066 [protein O-linked fucosylation] GO:0043065 [positive regulation of apoptotic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	1074 aa 116.5 kDa	Yes	0
ADAMTSL4-202 ENSP00000358035 ENST00000369039	Q6UY14 [Direct mapping] ADAMTS-like protein 4 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005578 [proteinaceous extracellular matrix] GO:0005614 [interstitial matrix] GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0008233 [peptidase activity] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0036066 [protein O-linked fucosylation] GO:0043065 [positive regulation of apoptotic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	1097 aa 118.8 kDa	Yes	0
ADAMTSL4-203 ENSP00000477897 ENST00000622417	A0A087WTI5 [Direct mapping] ADAMTS-like protein 4 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0031012 [extracellular matrix] Show all	435 aa 46.2 kDa	Yes	0

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The Human Protein Atlas

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