Expression of CERS2 in cancer - Summary - The Human Protein Atlas

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CERS2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CERS2
Gene description	Ceramide synthase 2
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA027262
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027262

GENE INFORMATION
Gene name	CERS2 (HGNC Symbol)
Synonyms	FLJ10243, LASS2, SP260
Description	Ceramide synthase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	150960583 - 150975004
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143418 (version 83.38)
Entrez gene	29956
UniProt	Q96G23 (UniProt - Evidence at protein level)
neXtProt	NX_Q96G23
Antibodypedia	CERS2 antibodies

PROTEIN BROWSER

CERS2-001	CERS2-003	CERS2-004	CERS2-005	CERS2-006	CERS2-009	CERS2-012	CERS2-013	CERS2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CERS2-001 ENSP00000357950 ENST00000368954	Q96G23 [Direct mapping] Ceramide synthase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006665 [sphingolipid metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030148 [sphingolipid biosynthetic process] GO:0031965 [nuclear membrane] GO:0044281 [small molecule metabolic process] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] Show all	380 aa 44.9 kDa	No	6
CERS2-003 ENSP00000357945 ENST00000368949	Q5SZE1 [Direct mapping] Ceramide synthase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] Show all	304 aa 36.4 kDa	No	6
CERS2-004 ENSP00000355020 ENST00000361419	Q5SZE4 [Direct mapping] Ceramide synthase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] Show all	249 aa 29.8 kDa	No	4
CERS2-005 ENSP00000394012 ENST00000457392	Q5SZE2 [Direct mapping] Ceramide synthase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] Show all	129 aa 15.4 kDa	No	1
CERS2-006 ENSP00000393239 ENST00000421609	Q5SZE3 [Direct mapping] Ceramide synthase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] Show all	192 aa 23.3 kDa	No	2
CERS2-009 ENSP00000452810 ENST00000558062	H0YKH6 [Direct mapping] Ceramide synthase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] Show all	223 aa 26.8 kDa	No	3
CERS2-012 ENSP00000454160 ENST00000561294	H0YNU7 [Direct mapping] Ceramide synthase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] Show all	377 aa 44.5 kDa	No	6
CERS2-013 ENSP00000453297 ENST00000560793	H0YLQ6 [Direct mapping] Ceramide synthase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] Show all	228 aa 26.6 kDa	No	4
CERS2-201 ENSP00000271688 ENST00000271688	Q96G23 [Direct mapping] Ceramide synthase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006665 [sphingolipid metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030148 [sphingolipid biosynthetic process] GO:0031965 [nuclear membrane] GO:0044281 [small molecule metabolic process] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] Show all	380 aa 44.9 kDa	No	6

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