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DYRK3

GENERAL INFORMATION

Gene name

 DYRK3

Gene description

 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 DYRK3 (HGNC Symbol)

Synonyms

 hYAK3-2, RED, REDK

Description

 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 (HGNC Symbol)

Entrez gene summary

 This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 206635536 - 206684419

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143479 (version 83.38)

Entrez gene

 8444

UniProt

 O43781 (UniProt - Evidence at transcript level)

neXtProt

 NX_O43781

Antibodypedia

 DYRK3 antibodies

PROTEIN BROWSER
DYRK3-001
DYRK3-002
DYRK3-004
DYRK3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DYRK3-001
ENSP00000356076
ENST00000367109
O43781 [Direct mapping]
Dual specificity tyrosine-phosphorylation-regulated kinase 3
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030218 [erythrocyte differentiation]
Show all
 588 aa
65.7 kDa 		No 0
DYRK3-002
ENSP00000356075
ENST00000367108
O43781 [Direct mapping]
Dual specificity tyrosine-phosphorylation-regulated kinase 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030218 [erythrocyte differentiation]
Show all
 568 aa
64 kDa 		No 0
DYRK3-004
ENSP00000356073
ENST00000367106
O43781 [Direct mapping]
Dual specificity tyrosine-phosphorylation-regulated kinase 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030218 [erythrocyte differentiation]
Show all
 568 aa
64 kDa 		No 0
DYRK3-005
ENSP00000410187
ENST00000441486
Q5SY34 [Direct mapping]
Dual-specificity tyrosine-phosphorylation-regulated kinase 3
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Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 243 aa
27.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.