Fields »
ABOUT
HELP
BLOG
EIF2D

GENERAL INFORMATION

Gene name

 EIF2D

Gene description

 Eukaryotic translation initiation factor 2D

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA028220
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028220

GENE INFORMATION

Gene name

 EIF2D (HGNC Symbol)

Synonyms

 LGTN

Description

 Eukaryotic translation initiation factor 2D (HGNC Symbol)

Entrez gene summary

 This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 206571292 - 206612463

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143486 (version 83.38)

Entrez gene

 1939

UniProt

 P41214 (UniProt - Evidence at protein level)

neXtProt

 NX_P41214

Antibodypedia

 EIF2D antibodies

PROTEIN BROWSER
EIF2D-001
EIF2D-002
EIF2D-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EIF2D-001
ENSP00000271764
ENST00000271764
P41214 [Direct mapping]
Eukaryotic translation initiation factor 2D
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001731 [formation of translation preinitiation complex]
GO:0002192 [IRES-dependent translational initiation]
GO:0003723 [RNA binding]
GO:0003743 [translation initiation factor activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006413 [translational initiation]
GO:0006886 [intracellular protein transport]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0032790 [ribosome disassembly]
Show all
 584 aa
64.7 kDa 		No 0
EIF2D-002
ENSP00000356081
ENST00000367114
P41214 [Direct mapping]
Eukaryotic translation initiation factor 2D
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001731 [formation of translation preinitiation complex]
GO:0002192 [IRES-dependent translational initiation]
GO:0003723 [RNA binding]
GO:0003743 [translation initiation factor activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006413 [translational initiation]
GO:0006886 [intracellular protein transport]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0032790 [ribosome disassembly]
Show all
 460 aa
51 kDa 		No 0
EIF2D-009
ENSP00000394685
ENST00000437518
Q5SY38 [Direct mapping]
Eukaryotic translation initiation factor 2D
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
Show all
 271 aa
29.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.