Expression of FLG2 in cancer - Summary - The Human Protein Atlas

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FLG2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FLG2
Gene description	Filaggrin family member 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (melanoma)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in cornified layer of epidermis.

ANTIBODY IHC RELIABILITY
Data reliability description	External characterization data supports antibody staining. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA028699
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028699

GENE INFORMATION
Gene name	FLG2 (HGNC Symbol)
Synonyms	IFPS
Description	Filaggrin family member 2 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	152348735 - 152360006
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143520 (version 83.38)
Entrez gene	388698
UniProt	Q5D862 (UniProt - Evidence at protein level)
neXtProt	NX_Q5D862
Antibodypedia	FLG2 antibodies

PROTEIN BROWSER

FLG2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FLG2-001 ENSP00000373370 ENST00000388718	Q5D862 [Direct mapping] Filaggrin-2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0061436 [establishment of skin barrier] GO:0070062 [extracellular exosome] Show all	2391 aa 248.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.