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S100A8
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

S100A8

Gene description

S100 calcium binding protein A8

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (bone marrow, esophagus, tonsil)
GTEx:Expressed in all
FANTOM5:Group enriched (cervix, uterine, esophagus, tonsil)

Protein evidence

Evidence at protein level

Protein expression

Selective nuclear and cytoplasmic expression in squamous epithelia, subsets of cells outside reaction centra of lymphoid tissues and subsets of bone marrow poietic cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Supported based on 2 antibodies.
HPA024372 , CAB002791
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (bone marrow, esophagus, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, esophagus, tonsil)

GENE INFORMATION

Gene name

S100A8 (HGNC Symbol)

Synonyms

60B8AG, CAGA, CFAG, CGLA, MRP8, P8

Description

S100 calcium binding protein A8 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q21.3

Chromosome location (bp)

153390032 - 153391188

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143546 (version 83.38)

Entrez gene

6279

UniProt

P05109 (UniProt - Evidence at protein level)

neXtProt

NX_P05109

Antibodypedia

S100A8 antibodies

PROTEIN BROWSER

S100A8-001
S100A8-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

S100A8-001
ENSP00000357722
ENST00000368733
P05109 [Direct mapping]
Protein S100-A8 Protein S100-A8, N-terminally processed
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001816 [cytokine production]
GO:0002523 [leukocyte migration involved in inflammatory response]
GO:0002526 [acute inflammatory response]
GO:0002544 [chronic inflammatory response]
GO:0002793 [positive regulation of peptide secretion]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006914 [autophagy]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008017 [microtubule binding]
GO:0008270 [zinc ion binding]
GO:0010043 [response to zinc ion]
GO:0014002 [astrocyte development]
GO:0018119 [peptidyl-cysteine S-nitrosylation]
GO:0030307 [positive regulation of cell growth]
GO:0030593 [neutrophil chemotaxis]
GO:0032119 [sequestering of zinc ion]
GO:0032496 [response to lipopolysaccharide]
GO:0032602 [chemokine production]
GO:0035662 [Toll-like receptor 4 binding]
GO:0042060 [wound healing]
GO:0042742 [defense response to bacterium]
GO:0045087 [innate immune response]
GO:0045471 [response to ethanol]
GO:0050544 [arachidonic acid binding]
GO:0050729 [positive regulation of inflammatory response]
GO:0050786 [RAGE receptor binding]
GO:0050832 [defense response to fungus]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051493 [regulation of cytoskeleton organization]
GO:0070062 [extracellular exosome]
GO:0070488 [neutrophil aggregation]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
93 aa
10.8 kDa
No 0
S100A8-002
ENSP00000357721
ENST00000368732
P05109 [Direct mapping]
Protein S100-A8 Protein S100-A8, N-terminally processed
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001816 [cytokine production]
GO:0002523 [leukocyte migration involved in inflammatory response]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006914 [autophagy]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008017 [microtubule binding]
GO:0008270 [zinc ion binding]
GO:0018119 [peptidyl-cysteine S-nitrosylation]
GO:0030307 [positive regulation of cell growth]
GO:0030593 [neutrophil chemotaxis]
GO:0032119 [sequestering of zinc ion]
GO:0032602 [chemokine production]
GO:0035662 [Toll-like receptor 4 binding]
GO:0042742 [defense response to bacterium]
GO:0045087 [innate immune response]
GO:0050544 [arachidonic acid binding]
GO:0050729 [positive regulation of inflammatory response]
GO:0050786 [RAGE receptor binding]
GO:0050832 [defense response to fungus]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051493 [regulation of cytoskeleton organization]
GO:0070062 [extracellular exosome]
GO:0070488 [neutrophil aggregation]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
93 aa
10.8 kDa
No 0

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