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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SNAPIN
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SNAPIN

Gene description

SNAP-associated protein

Protein class

Predicted intracellular proteins
Transporters

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA046974
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA046974

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues displayed moderate to strong cytoplasmic positivity. Several cases of skin, testicular, urothelial, cervical and gastric cancers were weakly stained or negative.

GENE INFORMATION

Gene name

SNAPIN (HGNC Symbol)

Synonyms

BLOC1S7, BORCS3, SNAPAP

Description

SNAP-associated protein (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Chromosome

1

Cytoband

q21.3

Chromosome location (bp)

153658654 - 153661830

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143553 (version 83.38)

Entrez gene

23557

UniProt

O95295 (UniProt - Evidence at protein level)

neXtProt

NX_O95295

Antibodypedia

SNAPIN antibodies

PROTEIN BROWSER

SNAPIN-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SNAPIN-001
ENSP00000357674
ENST00000368685
O95295 [Direct mapping]
SNARE-associated protein Snapin
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Transporters
   Transporter channels and pores
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000149 [SNARE binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008021 [synaptic vesicle]
GO:0008089 [anterograde axon cargo transport]
GO:0008333 [endosome to lysosome transport]
GO:0010977 [negative regulation of neuron projection development]
GO:0016032 [viral process]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016188 [synaptic vesicle maturation]
GO:0030054 [cell junction]
GO:0030133 [transport vesicle]
GO:0030141 [secretory granule]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030672 [synaptic vesicle membrane]
GO:0031083 [BLOC-1 complex]
GO:0031175 [neuron projection development]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0032438 [melanosome organization]
GO:0043393 [regulation of protein binding]
GO:0045202 [synapse]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048489 [synaptic vesicle transport]
GO:0048490 [anterograde synaptic vesicle transport]
GO:0072553 [terminal button organization]
GO:0097352 [autophagosome maturation]
GO:1902824 [positive regulation of late endosome to lysosome transport]
Show all
136 aa
14.9 kDa
No 0

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