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S100A7

GENERAL INFORMATION

Gene name

 S100A7

Gene description

 S100 calcium binding protein A7

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (cervical cancer, head and neck cancer, melanoma, urothelial cancer)
HPA (cell line):Cell line enhanced (HaCaT, SK-BR-3)
HPA (normal tissue):Group enriched (skin, tonsil)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expression in squamous epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA006997 , CAB001453 , CAB033766
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (cervical cancer, head and neck cancer, melanoma, urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA006997
CAB001453
CAB033766

GENE INFORMATION

Gene name

 S100A7 (HGNC Symbol)

Synonyms

 PSOR1, S100A7c

Description

 S100 calcium binding protein A7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153457744 - 153460701

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143556 (version 83.38)

Entrez gene

 6278

UniProt

 P31151 (UniProt - Evidence at protein level)

neXtProt

 NX_P31151

Antibodypedia

 S100A7 antibodies

PROTEIN BROWSER
S100A7-001
S100A7-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
S100A7-001
ENSP00000357712
ENST00000368723
P31151 [Direct mapping]
Protein S100-A7
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000302 [response to reactive oxygen species]
GO:0001525 [angiogenesis]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0008544 [epidermis development]
GO:0010820 [positive regulation of T cell chemotaxis]
GO:0030216 [keratinocyte differentiation]
GO:0032496 [response to lipopolysaccharide]
GO:0045087 [innate immune response]
GO:0050786 [RAGE receptor binding]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0051238 [sequestering of metal ion]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071624 [positive regulation of granulocyte chemotaxis]
GO:0090026 [positive regulation of monocyte chemotaxis]
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 101 aa
11.5 kDa 		No 0
S100A7-002
ENSP00000357711
ENST00000368722
P31151 [Direct mapping]
Protein S100-A7
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0001525 [angiogenesis]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0008544 [epidermis development]
GO:0010820 [positive regulation of T cell chemotaxis]
GO:0030216 [keratinocyte differentiation]
GO:0032496 [response to lipopolysaccharide]
GO:0045087 [innate immune response]
GO:0050786 [RAGE receptor binding]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0051238 [sequestering of metal ion]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071624 [positive regulation of granulocyte chemotaxis]
GO:0090026 [positive regulation of monocyte chemotaxis]
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 101 aa
11.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.