Expression of C1orf131 in cancer - Summary - The Human Protein Atlas

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C1orf131

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C1orf131
Gene description	Chromosome 1 open reading frame 131
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nucleolar expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA028452 , HPA029920
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028452	HPA029920

GENE INFORMATION
Gene name	C1orf131 (HGNC Symbol)
Synonyms	DKFZp547B1713
Description	Chromosome 1 open reading frame 131 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q42.2
Chromosome location (bp)	231223763 - 231241187
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143633 (version 83.38)
Entrez gene	128061
UniProt	Q8NDD1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NDD1
Antibodypedia	C1orf131 antibodies

PROTEIN BROWSER

C1orf131-001	C1orf131-002	C1orf131-003	C1orf131-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C1orf131-001 ENSP00000355609 ENST00000366649	Q8NDD1 [Direct mapping] Uncharacterized protein C1orf131 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0044822 [poly(A) RNA binding] Show all	293 aa 32.6 kDa	No	0
C1orf131-002 ENSP00000355611 ENST00000366651	Q8NDD1 [Direct mapping] Uncharacterized protein C1orf131 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0044822 [poly(A) RNA binding] Show all	292 aa 32.5 kDa	No	0
C1orf131-003 ENSP00000321341 ENST00000318906	Q5TBH9 [Direct mapping] Chromosome 1 open reading frame 131, isoform CRA_a; Uncharacterized protein C1orf131 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		249 aa 27.9 kDa	No	0
C1orf131-005 ENSP00000401677 ENST00000451322	Q5TBI2 [Direct mapping] Uncharacterized protein C1orf131 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		256 aa 28.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.