Expression of TTC13 in cancer - Summary - The Human Protein Atlas

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TTC13

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TTC13
Gene description	Tetratricopeptide repeat domain 13
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA018022
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), pancreatic cancer (favourable) and head and neck cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018022

GENE INFORMATION
Gene name	TTC13 (HGNC Symbol)
Synonyms	FLJ22584
Description	Tetratricopeptide repeat domain 13 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q42.2
Chromosome location (bp)	230906243 - 230978875
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143643 (version 83.38)
Entrez gene	79573
UniProt	Q8NBP0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NBP0
Antibodypedia	TTC13 antibodies

PROTEIN BROWSER

TTC13-001	TTC13-002	TTC13-006	TTC13-007	TTC13-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TTC13-001 ENSP00000355621 ENST00000366661	Q8NBP0 [Direct mapping] Tetratricopeptide repeat protein 13 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	860 aa 96.8 kDa	Yes	0
TTC13-002 ENSP00000355622 ENST00000366662	Q8NBP0 [Direct mapping] Tetratricopeptide repeat protein 13 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	806 aa 90.7 kDa	Yes	0
TTC13-006 ENSP00000428447 ENST00000486879	H0YB10 [Direct mapping] Tetratricopeptide repeat protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		123 aa 14.6 kDa	No	0
TTC13-007 ENSP00000428622 ENST00000522399	E5RHB3 [Direct mapping] Tetratricopeptide repeat protein 13 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	166 aa 17.8 kDa	Yes	0
TTC13-008 ENSP00000430385 ENST00000522821	H0YBV3 [Direct mapping] Tetratricopeptide repeat protein 13 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		186 aa 19.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.