Expression of RP5-862P8.2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

RP5-862P8.2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RP5-862P8.2
Gene description	Mitogen-activated protein kinase kinase kinase MLK4
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HEK93)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in adipose tissues and most glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA007636
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007636

GENE INFORMATION
Gene name	RP5-862P8.2
Synonyms
Description	Mitogen-activated protein kinase kinase kinase MLK4 (UniProtKB/Swiss-Prot)
Entrez gene summary
Chromosome	1
Cytoband	q42.2
Chromosome location (bp)	233327768 - 233385148
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143674 (version 83.38)
Entrez gene	84451
UniProt	Q5TCX8 (UniProt - Evidence at protein level)
neXtProt	NX_Q5TCX8
Antibodypedia	RP5-862P8.2 antibodies

PROTEIN BROWSER

RP5-862P8.2-001	RP5-862P8.2-002	RP5-862P8.2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RP5-862P8.2-001 ENSP00000355583 ENST00000366624	Q5TCX8 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase kinase kinase MLK4 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0007257 [activation of JUN kinase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0042803 [protein homodimerization activity] GO:0046777 [protein autophosphorylation] Show all	1036 aa 114 kDa	No	0
RP5-862P8.2-002 ENSP00000355582 ENST00000366623		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	570 aa 63 kDa	No	0
RP5-862P8.2-003 ENSP00000355581 ENST00000366622	X6R610 [Direct mapping] Mitogen-activated protein kinase kinase kinase MLK4 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		482 aa 52.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.