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NVL

GENERAL INFORMATION

Gene name

 NVL

Gene description

 Nuclear VCP-like

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nucleolar and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA028207 , HPA028224 , HPA028654
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and lung cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA028207
HPA028224
HPA028654

GENE INFORMATION

Gene name

 NVL

Synonyms

Description

 Nuclear VCP-like (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011]

Chromosome

 1

Cytoband

 q42.11

Chromosome location (bp)

 224227334 - 224330387

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143748 (version 83.38)

Entrez gene

 4931

UniProt

 O15381 (UniProt - Evidence at protein level)

neXtProt

 NX_O15381

Antibodypedia

 NVL antibodies

PROTEIN BROWSER
NVL-001
NVL-002
NVL-003
NVL-006
NVL-017
NVL-018
NVL-019
NVL-023
NVL-024
NVL-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NVL-001
ENSP00000281701
ENST00000281701
O15381 [Direct mapping]
Nuclear valosin-containing protein-like
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0042254 [ribosome biogenesis]
GO:0044822 [poly(A) RNA binding]
GO:0051973 [positive regulation of telomerase activity]
GO:1990275 [preribosome binding]
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 856 aa
95.1 kDa 		No 0
NVL-002
ENSP00000375747
ENST00000391875
O15381 [Direct mapping]
Nuclear valosin-containing protein-like
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0042254 [ribosome biogenesis]
GO:0044822 [poly(A) RNA binding]
GO:0051973 [positive regulation of telomerase activity]
GO:1990275 [preribosome binding]
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 750 aa
82.7 kDa 		No 0
NVL-003
ENSP00000419420
ENST00000469968
O15381 [Direct mapping]
Nuclear valosin-containing protein-like
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0042254 [ribosome biogenesis]
GO:0044822 [poly(A) RNA binding]
GO:0051973 [positive regulation of telomerase activity]
GO:1990275 [preribosome binding]
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 659 aa
72.7 kDa 		No 0
NVL-006
ENSP00000394884
ENST00000436927
C9JP83 [Direct mapping]
Nuclear valosin-containing protein-like
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 171 aa
18.7 kDa 		No 0
NVL-017
ENSP00000341362
ENST00000340871
O15381 [Direct mapping]
Nuclear valosin-containing protein-like
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0042254 [ribosome biogenesis]
GO:0044822 [poly(A) RNA binding]
GO:0051973 [positive regulation of telomerase activity]
GO:1990275 [preribosome binding]
Show all
 667 aa
73.3 kDa 		No 0
NVL-018
ENSP00000417826
ENST00000469075
O15381 [Direct mapping]
Nuclear valosin-containing protein-like
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0042254 [ribosome biogenesis]
GO:0044822 [poly(A) RNA binding]
GO:0051973 [positive regulation of telomerase activity]
GO:1990275 [preribosome binding]
Show all
 765 aa
85 kDa 		No 0
NVL-019
ENSP00000418085
ENST00000461546
E9PGD8 [Direct mapping]
Nuclear valosin-containing protein-like
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 175 aa
19.8 kDa 		No 0
NVL-023
ENSP00000418380
ENST00000492281
C9J6P7 [Direct mapping]
Nuclear valosin-containing protein-like
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
Show all
 180 aa
20.1 kDa 		No 0
NVL-024
ENSP00000419828
ENST00000488718
E7EWK7 [Direct mapping]
Nuclear valosin-containing protein-like
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 184 aa
21.1 kDa 		No 0
NVL-201
ENSP00000417213
ENST00000482491
O15381 [Direct mapping]
Nuclear valosin-containing protein-like
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0042254 [ribosome biogenesis]
GO:0044822 [poly(A) RNA binding]
GO:0051973 [positive regulation of telomerase activity]
GO:1990275 [preribosome binding]
Show all
 667 aa
73.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.