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ITPKB

GENERAL INFORMATION

Gene name

 ITPKB

Gene description

 Inositol-trisphosphate 3-kinase B

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SK-MEL-30)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in CNS, smooth muscle and lung.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA030273
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable) and lung cancer (favourable).
Head and neck cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA030273

GENE INFORMATION

Gene name

 ITPKB (HGNC Symbol)

Synonyms

 IP3-3KB, IP3KB

Description

 Inositol-trisphosphate 3-kinase B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q42.12

Chromosome location (bp)

 226631690 - 226739323

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143772 (version 83.38)

Entrez gene

 3707

UniProt

 P27987 (UniProt - Evidence at protein level)

neXtProt

 NX_P27987

Antibodypedia

 ITPKB antibodies

PROTEIN BROWSER
ITPKB-001
ITPKB-002
ITPKB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ITPKB-001
ENSP00000272117
ENST00000272117
P27987 [Direct mapping]
Inositol-trisphosphate 3-kinase B
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
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 946 aa
102.4 kDa 		No 0
ITPKB-002
ENSP00000355748
ENST00000366784
P27987 [Direct mapping]
Inositol-trisphosphate 3-kinase B
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 644 aa
67.4 kDa 		No 0
ITPKB-201
ENSP00000411152
ENST00000429204
P27987 [Direct mapping]
Inositol-trisphosphate 3-kinase B
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001932 [regulation of protein phosphorylation]
GO:0002262 [myeloid cell homeostasis]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016020 [membrane]
GO:0030217 [T cell differentiation]
GO:0033030 [negative regulation of neutrophil apoptotic process]
GO:0035726 [common myeloid progenitor cell proliferation]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045059 [positive thymic T cell selection]
GO:0045061 [thymic T cell selection]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046638 [positive regulation of alpha-beta T cell differentiation]
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 946 aa
102.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.