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CDC42BPA

GENERAL INFORMATION

Gene name

 CDC42BPA

Gene description

 CDC42 binding protein kinase alpha (DMPK-like)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CDC42BPA (HGNC Symbol)

Synonyms

 FLJ23347, KIAA0451, MRCK, MRCKA, PK428

Description

 CDC42 binding protein kinase alpha (DMPK-like) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q42.13

Chromosome location (bp)

 226989865 - 227318474

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143776 (version 83.38)

Entrez gene

 8476

UniProt

 Q5VT25 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5VT25

Antibodypedia

 CDC42BPA antibodies

PROTEIN BROWSER
CDC42BPA-001
CDC42BPA-002
CDC42BPA-003
CDC42BPA-004
CDC42BPA-005
CDC42BPA-006
CDC42BPA-007
CDC42BPA-201
CDC42BPA-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC42BPA-001
ENSP00000355731
ENST00000366769
Q5VT25 [Direct mapping]
Serine/threonine-protein kinase MRCK alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0007097 [nuclear migration]
GO:0016477 [cell migration]
GO:0031032 [actomyosin structure organization]
GO:0031252 [cell leading edge]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
GO:0042641 [actomyosin]
GO:0042802 [identical protein binding]
GO:0070062 [extracellular exosome]
Show all
 1719 aa
195.9 kDa 		No 0
CDC42BPA-002
ENSP00000355729
ENST00000366767
Q5VT25 [Direct mapping]
Serine/threonine-protein kinase MRCK alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0016477 [cell migration]
GO:0031032 [actomyosin structure organization]
GO:0031252 [cell leading edge]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
GO:0042641 [actomyosin]
GO:0042802 [identical protein binding]
GO:0070062 [extracellular exosome]
Show all
 1638 aa
186.1 kDa 		No 0
CDC42BPA-003
ENSP00000335341
ENST00000334218
Q5VT25 [Direct mapping]
Serine/threonine-protein kinase MRCK alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0016477 [cell migration]
GO:0031032 [actomyosin structure organization]
GO:0031252 [cell leading edge]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
GO:0042641 [actomyosin]
GO:0042802 [identical protein binding]
GO:0070062 [extracellular exosome]
Show all
 1732 aa
197.3 kDa 		No 0
CDC42BPA-004
ENSP00000401051
ENST00000442054
H0Y5V1 [Direct mapping]
Serine/threonine-protein kinase MRCK alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
Show all
 1048 aa
117.7 kDa 		No 0
CDC42BPA-005
ENSP00000408165
ENST00000441725
H0Y6V3 [Direct mapping]
Serine/threonine-protein kinase MRCK alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 728 aa
81.6 kDa 		No 0
CDC42BPA-006
ENSP00000415388
ENST00000448940
H0Y7V8 [Direct mapping]
Serine/threonine-protein kinase MRCK alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
Show all
 984 aa
109.9 kDa 		No 0
CDC42BPA-007
ENSP00000407120
ENST00000429440
H0Y6R0 [Direct mapping]
Serine/threonine-protein kinase MRCK alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0006468 [protein phosphorylation]
GO:0031532 [actin cytoskeleton reorganization]
Show all
 546 aa
61.7 kDa 		No 0
CDC42BPA-201
ENSP00000355726
ENST00000366764
A0A0A0MRJ0 [Direct mapping]
Non-specific serine/threonine protein kinase
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 1699 aa
193.6 kDa 		No 0
CDC42BPA-202
ENSP00000355728
ENST00000366766
A0A0A0MRJ1 [Direct mapping]
Serine/threonine-protein kinase MRCK alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 1018 aa
114.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.