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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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MBOAT2
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

MBOAT2

Gene description

Membrane bound O-acyltransferase domain containing 2

Protein class

Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Uncertain based on 1 antibody.
HPA014836
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PROGNOSTIC SUMMARY

Prognostic marker in endometrial cancer (unfavourable) and urothelial cancer (unfavourable).
Endometrial cancer p<0.001
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA014836

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues showed moderate to strong cytoplasmic immunoreactivity.

GENE INFORMATION

Gene name

MBOAT2 (HGNC Symbol)

Synonyms

FLJ14415, FLJ90298, OACT2

Description

Membrane bound O-acyltransferase domain containing 2 (HGNC Symbol)

Entrez gene summary

Chromosome

2

Cytoband

p25.1

Chromosome location (bp)

8852690 - 9003813

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143797 (version 83.38)

Entrez gene

129642

UniProt

Q6ZWT7 (UniProt - Evidence at transcript level)

neXtProt

NX_Q6ZWT7

Antibodypedia

MBOAT2 antibodies

PROTEIN BROWSER

MBOAT2-001
MBOAT2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MBOAT2-001
ENSP00000302177
ENST00000305997
Q6ZWT7 [Direct mapping]
Lysophospholipid acyltransferase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006644 [phospholipid metabolic process]
GO:0016021 [integral component of membrane]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0036152 [phosphatidylethanolamine acyl-chain remodeling]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
Show all
520 aa
59.5 kDa
No 9
MBOAT2-006
ENSP00000417409
ENST00000462696
C9J2H7 [Direct mapping]
Lysophospholipid acyltransferase 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
176 aa
19.6 kDa
No 3

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The Human Protein Atlas project is funded
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