Expression of MBOAT2 in cancer - Summary - The Human Protein Atlas

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MBOAT2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MBOAT2
Gene description	Membrane bound O-acyltransferase domain containing 2
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA014836
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and urothelial cancer (unfavourable).
Endometrial cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014836

GENE INFORMATION
Gene name	MBOAT2 (HGNC Symbol)
Synonyms	FLJ14415, FLJ90298, OACT2
Description	Membrane bound O-acyltransferase domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	p25.1
Chromosome location (bp)	8852690 - 9003813
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143797 (version 83.38)
Entrez gene	129642
UniProt	Q6ZWT7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6ZWT7
Antibodypedia	MBOAT2 antibodies

PROTEIN BROWSER

MBOAT2-001	MBOAT2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MBOAT2-001 ENSP00000302177 ENST00000305997	Q6ZWT7 [Direct mapping] Lysophospholipid acyltransferase 2 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0016021 [integral component of membrane] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	520 aa 59.5 kDa	No	9
MBOAT2-006 ENSP00000417409 ENST00000462696	C9J2H7 [Direct mapping] Lysophospholipid acyltransferase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	176 aa 19.6 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.