Expression of PYCR2 in cancer - Summary - The Human Protein Atlas

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PYCR2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PYCR2
Gene description	Pyrroline-5-carboxylate reductase family, member 2
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA056873
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA056873

GENE INFORMATION
Gene name	PYCR2 (HGNC Symbol)
Synonyms	P5CR2
Description	Pyrroline-5-carboxylate reductase family, member 2 (HGNC Symbol)
Entrez gene summary	This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Chromosome	1
Cytoband	q42.12
Chromosome location (bp)	225919877 - 225924340
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143811 (version 83.38)
Entrez gene	29920
UniProt	Q96C36 (UniProt - Evidence at protein level)
neXtProt	NX_Q96C36
Antibodypedia	PYCR2 antibodies

PROTEIN BROWSER

PYCR2-001	PYCR2-006	PYCR2-007	PYCR2-201	PYCR2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PYCR2-001 ENSP00000342502 ENST00000343818	Q96C36 [Direct mapping] Pyrroline-5-carboxylate reductase 2 Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0005759 [mitochondrial matrix] GO:0006561 [proline biosynthetic process] GO:0008652 [cellular amino acid biosynthetic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0055129 [L-proline biosynthetic process] Show all	320 aa 33.6 kDa	No	0
PYCR2-006 ENSP00000482614 ENST00000489681	A0A087WZF0 [Direct mapping] Pyrroline-5-carboxylate reductase 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	157 aa 16.6 kDa	No	0
PYCR2-007 ENSP00000480779 ENST00000472798	A0A087WX69 [Direct mapping] Pyrroline-5-carboxylate reductase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	87 aa 9.5 kDa	No	0
PYCR2-201 ENSP00000478165 ENST00000612039	A0A087WTV6 [Direct mapping] Pyrroline-5-carboxylate reductase 2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	246 aa 25.9 kDa	No	0
PYCR2-202 ENSP00000482845 ENST00000612651	A0A087WZR9 [Direct mapping] Pyrroline-5-carboxylate reductase Show all	SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] GO:0055129 [L-proline biosynthetic process] Show all	319 aa 33.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.