Expression of ETNK2 in cancer - Summary

GENERAL INFORMATION
Gene name	ETNK2
Gene description	Ethanolamine kinase 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (kidney, liver, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in renal tubules and seminiferus ducts of testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA057167
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable) and renal cancer (favourable).
Glioma p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA057167

GENE INFORMATION
Gene name	ETNK2 (HGNC Symbol)
Synonyms	EKI2, FLJ10761
Description	Ethanolamine kinase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of choline/ethanolamine kinase family which catalyzes the first step of phosphatidylethanolamine (PtdEtn) biosynthesis via the cytidine diphosphate (CDP) ethanolamine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	204131062 - 204152003
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143845 (version 83.38)
Entrez gene	55224
UniProt	Q9NVF9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NVF9
Antibodypedia	ETNK2 antibodies

PROTEIN BROWSER

ETNK2-001	ETNK2-002	ETNK2-003	ETNK2-007	ETNK2-008	ETNK2-009	ETNK2-010	ETNK2-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ETNK2-001 ENSP00000356170 ENST00000367202	Q9NVF9 [Direct mapping] Ethanolamine kinase 2 A0A024R9A8 [Target identity:100%; Query identity:100%] Ethanolamine kinase 2, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004305 [ethanolamine kinase activity] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006646 [phosphatidylethanolamine biosynthetic process] GO:0008150 [biological_process] GO:0016310 [phosphorylation] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	386 aa 44.8 kDa	No	0
ETNK2-002 ENSP00000356169 ENST00000367201	Q9NVF9 [Direct mapping] Ethanolamine kinase 2 A0A024R976 [Target identity:100%; Query identity:100%] Ethanolamine kinase 2, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Show all	GO:0001701 [in utero embryonic development] GO:0001890 [placenta development] GO:0004305 [ethanolamine kinase activity] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006646 [phosphatidylethanolamine biosynthetic process] GO:0008150 [biological_process] GO:0009791 [post-embryonic development] GO:0016310 [phosphorylation] GO:0035264 [multicellular organism growth] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	394 aa 44.8 kDa	No	0
ETNK2-003 ENSP00000405497 ENST00000422699	Q5SXX8 [Direct mapping] Ethanolamine kinase 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		217 aa 24.8 kDa	No	0
ETNK2-007 ENSP00000406241 ENST00000444817	Q5SXX7 [Direct mapping] Ethanolamine kinase 2 Show all	Predicted intracellular proteins Show all		148 aa 17.4 kDa	No	0
ETNK2-008 ENSP00000356165 ENST00000367197	Q5SXX4 [Direct mapping] Ethanolamine kinase 2 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all		68 aa 8.1 kDa	No	0
ETNK2-009 ENSP00000410580 ENST00000422072	H0Y771 [Direct mapping] Ethanolamine kinase 2 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Show all		149 aa 17.5 kDa	No	0
ETNK2-010 ENSP00000394618 ENST00000429525	B7ZC35 [Direct mapping] Ethanolamine kinase 2 Show all	Predicted intracellular proteins Show all		12 aa 1.4 kDa	No	0
ETNK2-011 ENSP00000398091 ENST00000452983	B7ZC34 [Direct mapping] Ethanolamine kinase 2 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all		192 aa 22.2 kDa	No	0