Cell atlas - SYT2 - The Human Protein Atlas

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SYT2

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	SYT2
Gene description	Synaptotagmin II
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Group enriched (AF22, NTERA-2, U-2 OS)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA030372
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (AF22, NTERA-2, U-2 OS) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA030372	A-431	Vesicles
	HPA030372	U-2 OS	Vesicles
	HPA030372	U-251 MG	Vesicles

GENE INFORMATION
Gene name	SYT2
Synonyms
Description	Synaptotagmin II (HGNC Symbol)
Entrez gene summary	This gene encodes a synaptic vesicle membrane protein. The encoded protein is thought to function as a calcium sensor in vesicular trafficking and exocytosis. Mutations in this gene are associated with myasthenic syndrome, presynaptic, congenital, with or without motor neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	202590596 - 202710417
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143858 (version 83.38)
Entrez gene	127833
UniProt	Q8N9I0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N9I0
Antibodypedia	SYT2 antibodies

PROTEIN BROWSER

SYT2-001	SYT2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SYT2-001 ENSP00000356237 ENST00000367268	Q8N9I0 [Direct mapping] Synaptotagmin-2 A0A024R9B3 [Target identity:100%; Query identity:100%] Synaptotagmin II, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0030054 [cell junction] GO:0030276 [clathrin binding] GO:0030672 [synaptic vesicle membrane] GO:0042584 [chromaffin granule membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0043533 [inositol 1,3,4,5 tetrakisphosphate binding] GO:0048488 [synaptic vesicle endocytosis] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] GO:1903861 [positive regulation of dendrite extension] Show all	419 aa 46.9 kDa	No	1
SYT2-002 ENSP00000356236 ENST00000367267	Q8N9I0 [Direct mapping] Synaptotagmin-2 A0A024R9B3 [Target identity:100%; Query identity:100%] Synaptotagmin II, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0030054 [cell junction] GO:0030276 [clathrin binding] GO:0030672 [synaptic vesicle membrane] GO:0042584 [chromaffin granule membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0043533 [inositol 1,3,4,5 tetrakisphosphate binding] GO:0048488 [synaptic vesicle endocytosis] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] GO:1903861 [positive regulation of dendrite extension] Show all	419 aa 46.9 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.