Fields »
ABOUT
HELP
BLOG
PDIA6

GENERAL INFORMATION

Gene name

 PDIA6

Gene description

 Protein disulfide isomerase family A, member 6

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression with a granular pattern in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA034652 , HPA034653 , CAB034347
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PDIA6 (HGNC Symbol)

Synonyms

 ERp5, P5, TXNDC7

Description

 Protein disulfide isomerase family A, member 6 (HGNC Symbol)

Entrez gene summary

 Protein disulfide isomerases (EC 5.3.4.1), such as PDIA6, are endoplasmic reticulum (ER) resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded proteins (Hayano and Kikuchi, 1995 [PubMed 7590364]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 p25.1

Chromosome location (bp)

 10783391 - 10837977

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143870 (version 83.38)

Entrez gene

 10130

UniProt

 Q15084 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15084

Antibodypedia

 PDIA6 antibodies

PROTEIN BROWSER
PDIA6-001
PDIA6-002
PDIA6-003
PDIA6-005
PDIA6-201
PDIA6-202
PDIA6-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDIA6-001
ENSP00000272227
ENST00000272227
Q15084 [Direct mapping]
Protein disulfide-isomerase A6
Show all
Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003756 [protein disulfide isomerase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0016853 [isomerase activity]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034663 [endoplasmic reticulum chaperone complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042470 [melanosome]
GO:0044267 [cellular protein metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0070062 [extracellular exosome]
Show all
 440 aa
48.1 kDa 		Yes 0
PDIA6-002
ENSP00000385385
ENST00000404371
Q15084 [Direct mapping]
Protein disulfide-isomerase A6
Show all
Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003756 [protein disulfide isomerase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0016853 [isomerase activity]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034663 [endoplasmic reticulum chaperone complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042470 [melanosome]
GO:0044267 [cellular protein metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0070062 [extracellular exosome]
Show all
 492 aa
53.9 kDa 		No 0
PDIA6-003
ENSP00000384459
ENST00000404824
Q15084 [Direct mapping]
Protein disulfide-isomerase A6
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003756 [protein disulfide isomerase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0016853 [isomerase activity]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034663 [endoplasmic reticulum chaperone complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042470 [melanosome]
GO:0044267 [cellular protein metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0070062 [extracellular exosome]
Show all
 488 aa
53.3 kDa 		No 1
PDIA6-005
ENSP00000389558
ENST00000458536
C9JNG5 [Direct mapping]
Protein disulfide-isomerase A6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0034976 [response to endoplasmic reticulum stress]
Show all
 11 aa
1.2 kDa 		No 0
PDIA6-201
ENSP00000371024
ENST00000381611
Q15084 [Direct mapping]
Protein disulfide-isomerase A6
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003756 [protein disulfide isomerase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0016853 [isomerase activity]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034663 [endoplasmic reticulum chaperone complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042470 [melanosome]
GO:0044267 [cellular protein metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0070062 [extracellular exosome]
Show all
 445 aa
48.6 kDa 		Yes 0
PDIA6-202
ENSP00000438778
ENST00000540494
Q15084 [Direct mapping]
Protein disulfide-isomerase A6
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003756 [protein disulfide isomerase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0016853 [isomerase activity]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034663 [endoplasmic reticulum chaperone complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042470 [melanosome]
GO:0044267 [cellular protein metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0070062 [extracellular exosome]
Show all
 437 aa
47.8 kDa 		Yes 0
PDIA6-203
ENSP00000481892
ENST00000617249
Q15084 [Direct mapping]
Protein disulfide-isomerase A6
Show all
Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003756 [protein disulfide isomerase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0016853 [isomerase activity]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034663 [endoplasmic reticulum chaperone complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042470 [melanosome]
GO:0044267 [cellular protein metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0070062 [extracellular exosome]
Show all
 492 aa
53.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.