Tissue expression of ASXL2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ASXL2
Gene description	Additional sex combs like transcriptional regulator 2
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ASXL2 (HGNC Symbol)
Synonyms	ASXH2, FLJ10898, KIAA1685
Description	Additional sex combs like transcriptional regulator 2 (HGNC Symbol)
Entrez gene summary	ASXL2 is a human homolog of the Drosophila asx gene. Drosophila asx is an enhancer of trithorax (see MIM 159555) and polycomb (see MIM 610231) (ETP) gene that encodes a chromatin protein with dual functions in transcriptional activation and silencing (Katoh and Katoh, 2003 [PubMed 12888926]).[supplied by OMIM, Sep 2009]
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	25733753 - 25878516
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143970 (version 83.38)
Entrez gene	55252
UniProt	Q76L83 (UniProt - Evidence at protein level)
neXtProt	NX_Q76L83
Antibodypedia	ASXL2 antibodies

PROTEIN BROWSER

ASXL2-001	ASXL2-004	ASXL2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASXL2-001 ENSP00000391447 ENST00000435504	Q76L83 [Direct mapping] Putative Polycomb group protein ASXL2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway] GO:0042975 [peroxisome proliferator activated receptor binding] GO:0045600 [positive regulation of fat cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	1435 aa 153.8 kDa	No	0
ASXL2-004 ENSP00000383920 ENST00000404843	Q76L83 [Direct mapping] Putative Polycomb group protein ASXL2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0003007 [heart morphogenesis] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0007507 [heart development] GO:0007512 [adult heart development] GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway] GO:0042975 [peroxisome proliferator activated receptor binding] GO:0045600 [positive regulation of fat cell differentiation] GO:0045672 [positive regulation of osteoclast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0048704 [embryonic skeletal system morphogenesis] GO:1900159 [positive regulation of bone mineralization involved in bone maturation] GO:1902466 [positive regulation of histone H3-K27 trimethylation] Show all	918 aa 98.4 kDa	No	0
ASXL2-201 ENSP00000337250 ENST00000336112	E7EWD6 [Direct mapping] Putative Polycomb group protein ASXL2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	1407 aa 150.5 kDa	No	0