Expression of EXOC6B in cancer - Summary - The Human Protein Atlas

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EXOC6B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EXOC6B
Gene description	Exocyst complex component 6B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA063991
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA063991

GENE INFORMATION
Gene name	EXOC6B (HGNC Symbol)
Synonyms	KIAA0919, SEC15B, SEC15L2
Description	Exocyst complex component 6B (HGNC Symbol)
Entrez gene summary	In yeast and rat, Sec15 is part of a multiprotein complex that is required for targeted exocytosis.[supplied by OMIM, Apr 2004]
Chromosome	2
Cytoband	p13.2
Chromosome location (bp)	72175984 - 72826041
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144036 (version 83.38)
Entrez gene	23233
UniProt	Q9Y2D4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2D4
Antibodypedia	EXOC6B antibodies

PROTEIN BROWSER

EXOC6B-001	EXOC6B-003	EXOC6B-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EXOC6B-001 ENSP00000272427 ENST00000272427	Q9Y2D4 [Direct mapping] Exocyst complex component 6B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0006904 [vesicle docking involved in exocytosis] GO:0015031 [protein transport] Show all	811 aa 94.2 kDa	No	0
EXOC6B-003 ENSP00000386698 ENST00000410104	J3QT38 [Direct mapping] Exocyst complex component 6B Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0006904 [vesicle docking involved in exocytosis] Show all	681 aa 79.4 kDa	No	0
EXOC6B-009 ENSP00000489442 ENST00000634650		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0006904 [vesicle docking involved in exocytosis] Show all	815 aa 94.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.