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DUSP11

GENERAL INFORMATION

Gene name

 DUSP11

Gene description

 Dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 DUSP11 (HGNC Symbol)

Synonyms

 PIR1

Description

 Dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]

Chromosome

 2

Cytoband

 p13.1

Chromosome location (bp)

 73762184 - 73780157

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144048 (version 83.38)

Entrez gene

 8446

UniProt

 O75319 (UniProt - Evidence at protein level)

neXtProt

 NX_O75319

Antibodypedia

 DUSP11 antibodies

PROTEIN BROWSER
DUSP11-001
DUSP11-002
DUSP11-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DUSP11-001
ENSP00000272444
ENST00000272444
O75319 [Direct mapping]
RNA/RNP complex-1-interacting phosphatase
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0004651 [polynucleotide 5'-phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005634 [nucleus]
GO:0006396 [RNA processing]
GO:0006470 [protein dephosphorylation]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016070 [RNA metabolic process]
GO:0016311 [dephosphorylation]
GO:0016607 [nuclear speck]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0044822 [poly(A) RNA binding]
GO:0098507 [polynucleotide 5' dephosphorylation]
GO:0098519 [nucleotide phosphatase activity, acting on free nucleotides]
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 377 aa
43.7 kDa 		No 0
DUSP11-002
ENSP00000413444
ENST00000443070
C9JYA6 [Direct mapping]
RNA/RNP complex-1-interacting phosphatase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
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 273 aa
30.6 kDa 		No 0
DUSP11-005
ENSP00000394535
ENST00000452812
H7C0E6 [Direct mapping]
RNA/RNP complex-1-interacting phosphatase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 150 aa
17.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.