Cell atlas - ST6GAL2 - The Human Protein Atlas

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ST6GAL2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ST6GAL2
Gene description	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli (fibrillar center). In addition localized to the nucleus.
RNA cell category	Cell line enhanced (U-266/70, U-138 MG, SCLC-21H, RPMI-8226, PC-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli fibrillar center (approved)
Additional location	In addition localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA014459
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70, U-138 MG, SCLC-21H, RPMI-8226, PC-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli (fibrillar center). In addition localized to the nucleus.

Main location

Nucleoli fibrillar center (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA014459	PC-3	Nucleus
	HPA014459	PC-3	Nucleoli fibrillar center
	HPA014459	SH-SY5Y	Nucleoli fibrillar center
	HPA014459	U-2 OS	Nucleus
	HPA014459	U-2 OS	Nucleoli fibrillar center

GENE INFORMATION
Gene name	ST6GAL2 (HGNC Symbol)
Synonyms	KIAA1877, SIAT2, St6gal2, St6GalII
Description	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 (HGNC Symbol)
Entrez gene summary	This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
Chromosome	2
Cytoband	q12.3
Chromosome location (bp)	106801600 - 106887108
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144057 (version 83.38)
Entrez gene	84620
UniProt	Q96JF0 (UniProt - Evidence at protein level)
neXtProt	NX_Q96JF0
Antibodypedia	ST6GAL2 antibodies

PROTEIN BROWSER

ST6GAL2-001	ST6GAL2-002	ST6GAL2-003	ST6GAL2-004	ST6GAL2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ST6GAL2-001 ENSP00000355273 ENST00000361686	Q96JF0 [Direct mapping] Beta-galactoside alpha-2,6-sialyltransferase 2 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0000139 [Golgi membrane] GO:0003824 [catalytic activity] GO:0003835 [beta-galactoside alpha-2,6-sialyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0007275 [multicellular organismal development] GO:0008373 [sialyltransferase activity] GO:0009311 [oligosaccharide metabolic process] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0032580 [Golgi cisterna membrane] GO:0040007 [growth] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0097503 [sialylation] Show all	529 aa 60.2 kDa	No	0
ST6GAL2-002 ENSP00000387332 ENST00000409087	Q96JF0 [Direct mapping] Beta-galactoside alpha-2,6-sialyltransferase 2 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0000139 [Golgi membrane] GO:0003824 [catalytic activity] GO:0003835 [beta-galactoside alpha-2,6-sialyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0007275 [multicellular organismal development] GO:0008373 [sialyltransferase activity] GO:0009311 [oligosaccharide metabolic process] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0032580 [Golgi cisterna membrane] GO:0040007 [growth] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0097503 [sialylation] Show all	466 aa 52.9 kDa	No	0
ST6GAL2-003 ENSP00000386942 ENST00000409382	Q96JF0 [Direct mapping] Beta-galactoside alpha-2,6-sialyltransferase 2 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0000139 [Golgi membrane] GO:0003824 [catalytic activity] GO:0003835 [beta-galactoside alpha-2,6-sialyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0007275 [multicellular organismal development] GO:0008373 [sialyltransferase activity] GO:0009311 [oligosaccharide metabolic process] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0032580 [Golgi cisterna membrane] GO:0040007 [growth] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0097503 [sialylation] Show all	529 aa 60.2 kDa	No	0
ST6GAL2-004 ENSP00000395581 ENST00000419159	C9JIK2 [Direct mapping] Beta-galactoside alpha-2,6-sialyltransferase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	35 aa 4.3 kDa	No	1
ST6GAL2-005 ENSP00000355386 ENST00000361803	H7BY52 [Direct mapping] Beta-galactoside alpha-2,6-sialyltransferase 2 Show all	Predicted intracellular proteins Show all	GO:0005794 [Golgi apparatus] GO:0006486 [protein glycosylation] GO:0008373 [sialyltransferase activity] GO:0016021 [integral component of membrane] GO:0097503 [sialylation] Show all	95 aa 10.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.