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RALB

GENERAL INFORMATION

Gene name

 RALB

Gene description

 V-ral simian leukemia viral oncogene homolog B

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic positvity in several tissues, including parathyroid gland.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending retesting.

Reliability score

 Approved based on 2 antibodies.
HPA065232 , CAB026010
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA065232
CAB026010

GENE INFORMATION

Gene name

 RALB

Synonyms

Description

 V-ral simian leukemia viral oncogene homolog B (HGNC Symbol)

Entrez gene summary

 This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q14.2

Chromosome location (bp)

 120240064 - 120294713

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144118 (version 83.38)

Entrez gene

 5899

UniProt

 P11234 (UniProt - Evidence at protein level)

neXtProt

 NX_P11234

Antibodypedia

 RALB antibodies

PROTEIN BROWSER
RALB-001
RALB-003
RALB-006
RALB-007
RALB-009
RALB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RALB-001
ENSP00000272519
ENST00000272519
P11234 [Direct mapping]
Ras-related protein Ral-B
A0A024RAG3 [Target identity:100%; Query identity:100%]
V-ral simian leukemia viral oncogene homolog B (Ras related GTP binding protein), isoform CRA_a
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0000910 [cytokinesis]
GO:0001928 [regulation of exocyst assembly]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005776 [autophagosome]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0008152 [metabolic process]
GO:0009267 [cellular response to starvation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051117 [ATPase binding]
GO:0060178 [regulation of exocyst localization]
GO:0070062 [extracellular exosome]
GO:0071360 [cellular response to exogenous dsRNA]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:2000786 [positive regulation of autophagosome assembly]
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 206 aa
23.4 kDa 		No 0
RALB-003
ENSP00000398162
ENST00000412383
C9J6B1 [Direct mapping]
Ras-related protein Ral-B
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0008152 [metabolic process]
GO:0015031 [protein transport]
GO:0016020 [membrane]
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 167 aa
18.7 kDa 		No 0
RALB-006
ENSP00000402866
ENST00000447591
C9JQB3 [Direct mapping]
Ras-related protein Ral-B
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0008152 [metabolic process]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 171 aa
19.3 kDa 		No 0
RALB-007
ENSP00000414224
ENST00000420510
P11234 [Direct mapping]
Ras-related protein Ral-B
A0A024RAG3 [Target identity:100%; Query identity:100%]
V-ral simian leukemia viral oncogene homolog B (Ras related GTP binding protein), isoform CRA_a
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0000910 [cytokinesis]
GO:0001928 [regulation of exocyst assembly]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005776 [autophagosome]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0008152 [metabolic process]
GO:0009267 [cellular response to starvation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051117 [ATPase binding]
GO:0060178 [regulation of exocyst localization]
GO:0070062 [extracellular exosome]
GO:0071360 [cellular response to exogenous dsRNA]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:2000786 [positive regulation of autophagosome assembly]
Show all
 206 aa
23.4 kDa 		No 0
RALB-009
ENSP00000407062
ENST00000449649
C9JYR1 [Direct mapping]
Ras-related protein Ral-B
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0008152 [metabolic process]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 112 aa
12.5 kDa 		No 0
RALB-201
ENSP00000487037
ENST00000631312
F8WEQ6 [Direct mapping]
Ras-related protein Ral-B
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0008152 [metabolic process]
Show all
 46 aa
4.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.